Jay Wright — Record When Ranked AP Top 15
281–65
81.2%
win rate
+11.0
avg margin
346
games
Games (346)
| # | Date | Season | School | Opponent | Opp. Conf. | Loc | W/L | Score | Type | Arena |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2005-11-18 | 2005–06 | #5 Villanova | Stony Brook | Am. East | Home | W | 78–35 | Regular | Xfinity Mobile Arena |
| 2 | 2005-11-27 | 2005–06 | #4 Villanova | Lehigh | Patriot | Home | W | 84–47 | Regular | Xfinity Mobile Arena |
| 3 | 2005-11-30 | 2005–06 | #4 Villanova | Rider | MAAC | Home | W | 86–57 | Regular | Xfinity Mobile Arena |
| 4 | 2005-12-03 | 2005–06 | #4 Villanova | #5 Oklahoma | B12 | Home | W | 85–74 | Regular | Xfinity Mobile Arena |
| 5 | 2005-12-06 | 2005–06 | #4 Villanova | Bucknell | Patriot | Away | W | 79–60 | Regular | Sojka Pavilion |
| 6 | 2005-12-10 | 2005–06 | #4 Villanova | Longwood | Independent | Neutral | W | 90–77 | Regular | Boardwalk Hall |
| 7 | 2005-12-13 | 2005–06 | #3 Villanova | Pennsylvania | Ivy | Away | W | 62–55 | Regular | The Palestra |
| 8 | 2005-12-22 | 2005–06 | #3 Villanova | La Salle | A10 | Home | W | 98–57 | Regular | Xfinity Mobile Arena |
| 9 | 2005-12-31 | 2005–06 | #3 Villanova | Temple | A10 | Neutral | W | 75–53 | Regular | The Palestra |
| 10 | 2006-01-05 | 2005–06 | #3 Villanova | #9 Louisville | Big East | Away | W | 76–67 | Regular | Freedom Hall |
| 11 | 2006-01-08 | 2005–06 | #3 Villanova | #24 West Virginia | Big East | Home | L | 87–91 | Regular | Finneran Pavilion |
| 12 | 2006-01-11 | 2005–06 | #3 Villanova | Rutgers | Big East | Away | W | 84–78 OT | Regular | Jersey Mike's Arena |
| 13 | 2006-01-14 | 2005–06 | #3 Villanova | #8 Texas | B12 | Away | L | 55–58 | Regular | Frank Erwin Center |
| 14 | 2006-01-17 | 2005–06 | #8 Villanova | Seton Hall | Big East | Home | W | 73–64 | Regular | Xfinity Mobile Arena |
| 15 | 2006-01-21 | 2005–06 | #8 Villanova | #20 Syracuse | Big East | Home | W | 80–65 | Regular | Xfinity Mobile Arena |
| 16 | 2006-01-24 | 2005–06 | #6 Villanova | South Florida | Big East | Away | W | 49–46 | Regular | Yuengling Center |
| 17 | 2006-01-28 | 2005–06 | #6 Villanova | Notre Dame | Big East | Away | W | 72–70 | Regular | Purcell Pavilion |
| 18 | 2006-01-30 | 2005–06 | #4 Villanova | Louisville | Big East | Home | W | 79–73 | Regular | Xfinity Mobile Arena |
| 19 | 2006-02-04 | 2005–06 | #4 Villanova | Marquette | Big East | Home | W | 72–67 | Regular | Xfinity Mobile Arena |
| 20 | 2006-02-07 | 2005–06 | #4 Villanova | Saint Joseph's | A10 | Neutral | W | 71–58 | Regular | The Palestra |
| 21 | 2006-02-11 | 2005–06 | #4 Villanova | DePaul | Big East | Away | W | 61–51 | Regular | Allstate Arena |
| 22 | 2006-02-13 | 2005–06 | #4 Villanova | #1 Connecticut | Big East | Home | W | 69–64 | Regular | Xfinity Mobile Arena |
| 23 | 2006-02-19 | 2005–06 | #4 Villanova | #17 Georgetown | Big East | Home | W | 75–65 | Regular | Xfinity Mobile Arena |
| 24 | 2006-02-23 | 2005–06 | #2 Villanova | Cincinnati | Big East | Away | W | 74–72 | Regular | Fifth Third Arena |
| 25 | 2006-02-26 | 2005–06 | #2 Villanova | #3 Connecticut | Big East | Away | L | 75–89 | Regular | Harry A. Gampel Pavilion |
| 26 | 2006-03-01 | 2005–06 | #4 Villanova | St. John's (NY) | Big East | Home | W | 65–52 | Regular | Xfinity Mobile Arena |
| 27 | 2006-03-05 | 2005–06 | #4 Villanova | Syracuse | Big East | Away | W | 92–82 | Regular | Carrier Dome |
| 28 | 2006-03-09 | 2005–06 | #2 Villanova | Rutgers | Big East | Neutral | W | 87–55 | Conf. Tourn. | Madison Square Garden |
| 29 | 2006-03-10 | 2005–06 | #2 Villanova | #15 Pittsburgh | Big East | Neutral | L | 54–68 | Conf. Tourn. | Madison Square Garden |
| 30 | 2008-12-09 | 2008–09 | #15 Villanova | #6 Texas | B12 | Neutral | L | 58–67 | Regular | Madison Square Garden |
| 31 | 2008-12-11 | 2008–09 | #15 Villanova | Saint Joseph's | A10 | Home | W | 59–56 | Regular | Xfinity Mobile Arena |
| 32 | 2008-12-14 | 2008–09 | #15 Villanova | La Salle | A10 | Away | W | 70–59 | Regular | John Glaser Arena |
| 33 | 2008-12-29 | 2008–09 | #15 Villanova | Temple | A10 | Home | W | 62–45 | Regular | Xfinity Mobile Arena |
| 34 | 2009-01-01 | 2008–09 | #15 Villanova | Marquette | Big East | Away | L | 72–79 | Regular | Bradley Center |
| 35 | 2009-02-10 | 2008–09 | #13 Villanova | #10 Marquette | Big East | Home | W | 102–84 | Regular | Xfinity Mobile Arena |
| 36 | 2009-02-13 | 2008–09 | #13 Villanova | West Virginia | Big East | Away | L | 72–93 | Regular | Hope Coliseum |
| 37 | 2009-02-19 | 2008–09 | #12 Villanova | Rutgers | Big East | Home | W | 82–72 | Regular | Xfinity Mobile Arena |
| 38 | 2009-02-22 | 2008–09 | #12 Villanova | #24 Syracuse | Big East | Away | W | 89–86 | Regular | Carrier Dome |
| 39 | 2009-02-25 | 2008–09 | #10 Villanova | DePaul | Big East | Away | W | 74–72 | Regular | Allstate Arena |
| 40 | 2009-02-28 | 2008–09 | #10 Villanova | Georgetown | Big East | Home | L | 54–56 | Regular | Xfinity Mobile Arena |
| 41 | 2009-03-02 | 2008–09 | #11 Villanova | Notre Dame | Big East | Away | W | 77–60 | Regular | Purcell Pavilion |
| 42 | 2009-03-05 | 2008–09 | #11 Villanova | Providence | Big East | Home | W | 97–80 | Regular | Xfinity Mobile Arena |
| 43 | 2009-03-12 | 2008–09 | #10 Villanova | #21 Marquette | Big East | Neutral | W | 76–75 | Conf. Tourn. | Madison Square Garden |
| 44 | 2009-03-13 | 2008–09 | #10 Villanova | #5 Louisville | Big East | Neutral | L | 55–69 | Conf. Tourn. | Madison Square Garden |
| 45 | 2009-11-13 | 2009–10 | #5 Villanova | FDU | NEC | Home | W | 84–61 | Regular | Xfinity Mobile Arena |
| 46 | 2009-11-16 | 2009–10 | #5 Villanova | Pennsylvania | Ivy | Home | W | 103–65 | Regular | Xfinity Mobile Arena |
| 47 | 2009-11-19 | 2009–10 | #5 Villanova | George Mason | Colonial | Neutral | W | 69–68 | Regular | José Miguel Agrelot Coliseum |
| 48 | 2009-11-20 | 2009–10 | #5 Villanova | #18 Dayton | A10 | Neutral | W | 71–65 | Regular | José Miguel Agrelot Coliseum |
| 49 | 2009-11-22 | 2009–10 | #5 Villanova | Mississippi | SEC | Neutral | W | 79–67 | Regular | José Miguel Agrelot Coliseum |
| 50 | 2009-11-28 | 2009–10 | #4 Villanova | La Salle | A10 | Home | W | 81–63 | Regular | Xfinity Mobile Arena |
| 51 | 2009-12-02 | 2009–10 | #3 Villanova | Drexel | Colonial | Home | W | 77–58 | Regular | Xfinity Mobile Arena |
| 52 | 2009-12-06 | 2009–10 | #3 Villanova | Maryland | ACC | Neutral | W | 95–86 | Regular | Capital One Arena |
| 53 | 2009-12-09 | 2009–10 | #3 Villanova | Saint Joseph's | A10 | Neutral | W | 97–89 | Regular | The Palestra |
| 54 | 2009-12-13 | 2009–10 | #3 Villanova | Temple | A10 | Away | L | 65–75 | Regular | Liacouras Center |
| 55 | 2009-12-19 | 2009–10 | #8 Villanova | Fordham | A10 | Neutral | W | 96–58 | Regular | Meadowlands Arena |
| 56 | 2009-12-23 | 2009–10 | #8 Villanova | Delaware | Colonial | Home | W | 97–63 | Regular | Xfinity Mobile Arena |
| 57 | 2010-01-02 | 2009–10 | #8 Villanova | Marquette | Big East | Away | W | 74–72 | Regular | Bradley Center |
| 58 | 2010-01-06 | 2009–10 | #6 Villanova | DePaul | Big East | Home | W | 99–72 | Regular | Xfinity Mobile Arena |
| 59 | 2010-01-09 | 2009–10 | #6 Villanova | Marquette | Big East | Home | W | 78–76 | Regular | Finneran Pavilion |
| 60 | 2010-01-11 | 2009–10 | #4 Villanova | Louisville | Big East | Away | W | 92–84 | Regular | Freedom Hall |
| 61 | 2010-01-17 | 2009–10 | #4 Villanova | #11 Georgetown | Big East | Home | W | 82–77 | Regular | Xfinity Mobile Arena |
| 62 | 2010-01-20 | 2009–10 | #4 Villanova | Rutgers | Big East | Away | W | 94–68 | Regular | Jersey Mike's Arena |
| 63 | 2010-01-23 | 2009–10 | #4 Villanova | St. John's (NY) | Big East | Away | W | 81–71 | Regular | Madison Square Garden |
| 64 | 2010-01-27 | 2009–10 | #3 Villanova | Notre Dame | Big East | Home | W | 90–72 | Regular | Xfinity Mobile Arena |
| 65 | 2010-02-02 | 2009–10 | #2 Villanova | Seton Hall | Big East | Home | W | 81–71 | Regular | Xfinity Mobile Arena |
| 66 | 2010-02-06 | 2009–10 | #2 Villanova | #7 Georgetown | Big East | Away | L | 90–103 | Regular | Capital One Arena |
| 67 | 2010-02-08 | 2009–10 | #4 Villanova | #5 West Virginia | Big East | Away | W | 82–75 | Regular | Hope Coliseum |
| 68 | 2010-02-13 | 2009–10 | #4 Villanova | Providence | Big East | Home | W | 92–81 | Regular | Xfinity Mobile Arena |
| 69 | 2010-02-15 | 2009–10 | #3 Villanova | Connecticut | Big East | Home | L | 75–84 | Regular | Xfinity Mobile Arena |
| 70 | 2010-02-21 | 2009–10 | #3 Villanova | #19 Pittsburgh | Big East | Away | L | 65–70 | Regular | Petersen Events Center |
| 71 | 2010-02-24 | 2009–10 | #7 Villanova | South Florida | Big East | Home | W | 74–49 | Regular | Xfinity Mobile Arena |
| 72 | 2010-02-27 | 2009–10 | #7 Villanova | #4 Syracuse | Big East | Away | L | 77–95 | Regular | Carrier Dome |
| 73 | 2010-03-02 | 2009–10 | #9 Villanova | Cincinnati | Big East | Away | W | 77–73 | Regular | Fifth Third Arena |
| 74 | 2010-03-06 | 2009–10 | #9 Villanova | #10 West Virginia | Big East | Home | L | 66–68 OT | Regular | Xfinity Mobile Arena |
| 75 | 2010-03-11 | 2009–10 | #10 Villanova | Marquette | Big East | Neutral | L | 76–80 | Conf. Tourn. | Madison Square Garden |
| 76 | 2010-11-12 | 2010–11 | #6 Villanova | Bucknell | Patriot | Home | W | 68–52 | Regular | Finneran Pavilion |
| 77 | 2010-11-16 | 2010–11 | #6 Villanova | Marist | MAAC | Home | W | 84–47 | Regular | Finneran Pavilion |
| 78 | 2010-11-17 | 2010–11 | #6 Villanova | Boston University | Am. East | Home | W | 82–66 | Regular | Finneran Pavilion |
| 79 | 2010-11-20 | 2010–11 | #6 Villanova | Lafayette | Patriot | Home | W | 86–41 | Regular | Finneran Pavilion |
| 80 | 2010-11-24 | 2010–11 | #7 Villanova | UCLA | Pacific 10 | Neutral | W | 82–70 | Regular | Madison Square Garden |
| 81 | 2010-11-26 | 2010–11 | #7 Villanova | #24 Tennessee | SEC | Neutral | L | 68–78 | Regular | Madison Square Garden |
| 82 | 2010-12-03 | 2010–11 | #12 Villanova | Saint Joseph's | A10 | Home | W | 71–60 | Regular | Finneran Pavilion |
| 83 | 2010-12-08 | 2010–11 | #12 Villanova | Pennsylvania | Ivy | Away | W | 65–53 | Regular | The Palestra |
| 84 | 2010-12-12 | 2010–11 | #12 Villanova | La Salle | A10 | Away | W | 84–81 | Regular | John Glaser Arena |
| 85 | 2010-12-18 | 2010–11 | #10 Villanova | Delaware | Colonial | Home | W | 78–59 | Regular | Xfinity Mobile Arena |
| 86 | 2010-12-22 | 2010–11 | #8 Villanova | Monmouth | NEC | Away | W | 76–36 | Regular | OceanFirst Bank Center |
| 87 | 2010-12-30 | 2010–11 | #8 Villanova | #25 Temple | A10 | Home | W | 78–74 | Regular | Finneran Pavilion |
| 88 | 2011-01-02 | 2010–11 | #8 Villanova | Rutgers | Big East | Home | W | 81–65 | Regular | Finneran Pavilion |
| 89 | 2011-01-06 | 2010–11 | #7 Villanova | South Florida | Big East | Away | W | 83–71 | Regular | Yuengling Center |
| 90 | 2011-01-09 | 2010–11 | #7 Villanova | #24 Cincinnati | Big East | Home | W | 72–61 | Regular | Finneran Pavilion |
| 91 | 2011-01-12 | 2010–11 | #7 Villanova | #18 Louisville | Big East | Home | W | 88–74 | Regular | Finneran Pavilion |
| 92 | 2011-01-15 | 2010–11 | #7 Villanova | Maryland | ACC | Home | W | 74–66 | Regular | Xfinity Mobile Arena |
| 93 | 2011-01-17 | 2010–11 | #7 Villanova | #8 Connecticut | Big East | Away | L | 59–61 | Regular | Harry A. Gampel Pavilion |
| 94 | 2011-01-22 | 2010–11 | #7 Villanova | #3 Syracuse | Big East | Away | W | 83–72 | Regular | Carrier Dome |
| 95 | 2011-01-26 | 2010–11 | #8 Villanova | Providence | Big East | Away | L | 68–83 | Regular | Amica Mutual Pavilion |
| 96 | 2011-01-29 | 2010–11 | #8 Villanova | #21 Georgetown | Big East | Home | L | 66–69 | Regular | Finneran Pavilion |
| 97 | 2011-02-02 | 2010–11 | #12 Villanova | Marquette | Big East | Home | W | 75–70 | Regular | Finneran Pavilion |
| 98 | 2011-02-05 | 2010–11 | #12 Villanova | #25 West Virginia | Big East | Home | W | 66–50 | Regular | Finneran Pavilion |
| 99 | 2011-02-09 | 2010–11 | #9 Villanova | Rutgers | Big East | Away | L | 76–77 | Regular | Jersey Mike's Arena |
| 100 | 2011-02-12 | 2010–11 | #9 Villanova | #4 Pittsburgh | Big East | Home | L | 54–57 | Regular | Finneran Pavilion |
| 101 | 2011-02-15 | 2010–11 | #15 Villanova | Seton Hall | Big East | Away | W | 60–57 | Regular | Prudential Center |
| 102 | 2011-02-19 | 2010–11 | #15 Villanova | DePaul | Big East | Away | W | 77–75 OT | Regular | Allstate Arena |
| 103 | 2011-02-21 | 2010–11 | #15 Villanova | #17 Syracuse | Big East | Home | L | 64–69 | Regular | Finneran Pavilion |
| 104 | 2011-02-26 | 2010–11 | #15 Villanova | #23 St. John's (NY) | Big East | Home | L | 68–81 | Regular | Xfinity Mobile Arena |
| 105 | 2013-12-04 | 2013–14 | #14 Villanova | Pennsylvania | Ivy | Home | W | 77–54 | Regular | Xfinity Mobile Arena |
| 106 | 2013-12-07 | 2013–14 | #14 Villanova | Saint Joseph's | A10 | Away | W | 98–68 | Regular | Hagan Arena |
| 107 | 2013-12-15 | 2013–14 | #10 Villanova | La Salle | A10 | Home | W | 73–52 | Regular | Xfinity Mobile Arena |
| 108 | 2013-12-21 | 2013–14 | #8 Villanova | Rider | MAAC | Home | W | 88–67 | Regular | Xfinity Mobile Arena |
| 109 | 2013-12-28 | 2013–14 | #8 Villanova | #2 Syracuse | ACC | Away | L | 62–78 | Regular | Carrier Dome |
| 110 | 2013-12-31 | 2013–14 | #11 Villanova | Butler | Big East | Away | W | 76–73 OT | Regular | Hinkle Fieldhouse |
| 111 | 2014-01-05 | 2013–14 | #11 Villanova | Providence | Big East | Home | W | 91–61 | Regular | Xfinity Mobile Arena |
| 112 | 2014-01-08 | 2013–14 | #8 Villanova | Seton Hall | Big East | Away | W | 83–67 | Regular | Prudential Center |
| 113 | 2014-01-11 | 2013–14 | #8 Villanova | St. John's (NY) | Big East | Away | W | 74–67 | Regular | Madison Square Garden |
| 114 | 2014-01-18 | 2013–14 | #6 Villanova | DePaul | Big East | Home | W | 88–62 | Regular | Xfinity Mobile Arena |
| 115 | 2014-01-20 | 2013–14 | #4 Villanova | Creighton | Big East | Home | L | 68–96 | Regular | Xfinity Mobile Arena |
| 116 | 2014-01-25 | 2013–14 | #4 Villanova | Marquette | Big East | Away | W | 94–85 OT | Regular | Bradley Center |
| 117 | 2014-01-27 | 2013–14 | #9 Villanova | Georgetown | Big East | Away | W | 65–60 | Regular | Capital One Arena |
| 118 | 2014-02-01 | 2013–14 | #9 Villanova | Temple | AAC | Away | W | 90–74 | Regular | Liacouras Center |
| 119 | 2014-02-03 | 2013–14 | #6 Villanova | Xavier | Big East | Home | W | 81–58 | Regular | Xfinity Mobile Arena |
| 120 | 2014-02-07 | 2013–14 | #6 Villanova | Seton Hall | Big East | Home | W | 70–53 | Regular | Xfinity Mobile Arena |
| 121 | 2014-02-12 | 2013–14 | #6 Villanova | DePaul | Big East | Away | W | 87–62 | Regular | Allstate Arena |
| 122 | 2014-02-16 | 2013–14 | #6 Villanova | #18 Creighton | Big East | Away | L | 80–101 | Regular | CHI Health Center Omaha |
| 123 | 2014-02-18 | 2013–14 | #9 Villanova | Providence | Big East | Away | W | 82–79 2OT | Regular | Amica Mutual Pavilion |
| 124 | 2014-02-22 | 2013–14 | #9 Villanova | St. John's (NY) | Big East | Home | W | 57–54 | Regular | Xfinity Mobile Arena |
| 125 | 2014-02-26 | 2013–14 | #8 Villanova | Butler | Big East | Home | W | 67–48 | Regular | Xfinity Mobile Arena |
| 126 | 2014-03-02 | 2013–14 | #8 Villanova | Marquette | Big East | Home | W | 73–56 | Regular | Xfinity Mobile Arena |
| 127 | 2014-03-06 | 2013–14 | #6 Villanova | Xavier | Big East | Away | W | 77–70 | Regular | Cintas Center |
| 128 | 2014-03-08 | 2013–14 | #6 Villanova | Georgetown | Big East | Home | W | 77–59 | Regular | Xfinity Mobile Arena |
| 129 | 2014-03-13 | 2013–14 | #3 Villanova | Seton Hall | Big East | Neutral | L | 63–64 | Conf. Tourn. | Madison Square Garden |
| 130 | 2014-11-14 | 2014–15 | #12 Villanova | Lehigh | Patriot | Neutral | W | 77–66 | Regular | PPL Center |
| 131 | 2014-11-17 | 2014–15 | #12 Villanova | Maryland-Eastern Shore | MEAC | Home | W | 81–44 | Regular | Finneran Pavilion |
| 132 | 2014-11-20 | 2014–15 | #12 Villanova | Bucknell | Patriot | Home | W | 72–65 | Regular | Finneran Pavilion |
| 133 | 2014-11-24 | 2014–15 | #12 Villanova | #14 Virginia Commonwealth | A10 | Neutral | W | 77–53 | Regular | Barclays Center |
| 134 | 2014-11-25 | 2014–15 | #12 Villanova | #19 Michigan | B10 | Neutral | W | 60–55 | Regular | Barclays Center |
| 135 | 2014-11-30 | 2014–15 | #12 Villanova | Delaware | Colonial | Neutral | W | 78–47 | Regular | Finneran Pavilion |
| 136 | 2014-12-03 | 2014–15 | #10 Villanova | La Salle | A10 | Away | W | 84–70 | Regular | John Glaser Arena |
| 137 | 2014-12-06 | 2014–15 | #10 Villanova | Saint Joseph's | A10 | Home | W | 74–46 | Regular | Finneran Pavilion |
| 138 | 2014-12-09 | 2014–15 | #7 Villanova | Illinois | B10 | Neutral | W | 73–59 | Regular | Madison Square Garden |
| 139 | 2014-12-14 | 2014–15 | #7 Villanova | Temple | AAC | Home | W | 85–62 | Regular | Finneran Pavilion |
| 140 | 2014-12-20 | 2014–15 | #7 Villanova | Syracuse | ACC | Home | W | 82–77 OT | Regular | Xfinity Mobile Arena |
| 141 | 2014-12-23 | 2014–15 | #7 Villanova | NJIT | Independent | Home | W | 92–67 | Regular | Finneran Pavilion |
| 142 | 2014-12-31 | 2014–15 | #6 Villanova | Butler | Big East | Home | W | 67–55 | Regular | Finneran Pavilion |
| 143 | 2015-01-03 | 2014–15 | #6 Villanova | Seton Hall | Big East | Away | L | 61–66 OT | Regular | Prudential Center |
| 144 | 2015-01-06 | 2014–15 | #8 Villanova | #24 St. John's (NY) | Big East | Away | W | 90–72 | Regular | Madison Square Garden |
| 145 | 2015-01-10 | 2014–15 | #8 Villanova | DePaul | Big East | Home | W | 81–64 | Regular | Finneran Pavilion |
| 146 | 2015-01-14 | 2014–15 | #5 Villanova | Xavier | Big East | Home | W | 88–75 | Regular | Finneran Pavilion |
| 147 | 2015-01-17 | 2014–15 | #5 Villanova | Pennsylvania | Ivy | Away | W | 62–47 | Regular | The Palestra |
| 148 | 2015-01-19 | 2014–15 | #4 Villanova | Georgetown | Big East | Away | L | 58–78 | Regular | Capital One Arena |
| 149 | 2015-01-25 | 2014–15 | #4 Villanova | Creighton | Big East | Home | W | 71–50 | Regular | Finneran Pavilion |
| 150 | 2015-01-31 | 2014–15 | #7 Villanova | DePaul | Big East | Away | W | 68–55 | Regular | Allstate Arena |
| 151 | 2015-02-04 | 2014–15 | #7 Villanova | Marquette | Big East | Home | W | 70–52 | Regular | Xfinity Mobile Arena |
| 152 | 2015-02-07 | 2014–15 | #7 Villanova | #24 Georgetown | Big East | Home | W | 69–53 | Regular | Finneran Pavilion |
| 153 | 2015-02-11 | 2014–15 | #6 Villanova | Providence | Big East | Away | W | 74–68 | Regular | Amica Mutual Pavilion |
| 154 | 2015-02-14 | 2014–15 | #6 Villanova | #18 Butler | Big East | Away | W | 68–65 | Regular | Hinkle Fieldhouse |
| 155 | 2015-02-16 | 2014–15 | #6 Villanova | Seton Hall | Big East | Home | W | 80–54 | Regular | Finneran Pavilion |
| 156 | 2015-02-21 | 2014–15 | #6 Villanova | Marquette | Big East | Away | W | 87–76 | Regular | Bradley Center |
| 157 | 2015-02-24 | 2014–15 | #6 Villanova | #25 Providence | Big East | Home | W | 89–61 | Regular | Finneran Pavilion |
| 158 | 2015-02-28 | 2014–15 | #6 Villanova | Xavier | Big East | Away | W | 78–66 | Regular | Cintas Center |
| 159 | 2015-03-03 | 2014–15 | #4 Villanova | Creighton | Big East | Away | W | 76–72 | Regular | CHI Health Center Omaha |
| 160 | 2015-03-07 | 2014–15 | #4 Villanova | St. John's (NY) | Big East | Home | W | 105–68 | Regular | Xfinity Mobile Arena |
| 161 | 2015-03-12 | 2014–15 | #4 Villanova | Marquette | Big East | Neutral | W | 84–49 | Conf. Tourn. | Madison Square Garden |
| 162 | 2015-03-13 | 2014–15 | #4 Villanova | Providence | Big East | Neutral | W | 63–61 | Conf. Tourn. | Madison Square Garden |
| 163 | 2015-03-14 | 2014–15 | #4 Villanova | Xavier | Big East | Neutral | W | 69–52 | Conf. Tourn. | Madison Square Garden |
| 164 | 2015-11-13 | 2015–16 | #11 Villanova | FDU | NEC | Home | W | 91–54 | Regular | Finneran Pavilion |
| 165 | 2015-11-17 | 2015–16 | #11 Villanova | Nebraska | B10 | Home | W | 87–63 | Regular | Finneran Pavilion |
| 166 | 2015-11-20 | 2015–16 | #11 Villanova | East Tennessee State | SoCon | Home | W | 86–51 | Regular | Finneran Pavilion |
| 167 | 2015-11-22 | 2015–16 | #11 Villanova | Akron | MAC | Home | W | 75–56 | Regular | Finneran Pavilion |
| 168 | 2015-11-26 | 2015–16 | #8 Villanova | Stanford | Pacific 12 | Neutral | W | 59–45 | Regular | Barclays Center |
| 169 | 2015-11-27 | 2015–16 | #8 Villanova | Georgia Tech | ACC | Neutral | W | 69–52 | Regular | Barclays Center |
| 170 | 2015-12-01 | 2015–16 | #8 Villanova | Saint Joseph's | A10 | Away | W | 86–72 | Regular | Hagan Arena |
| 171 | 2015-12-07 | 2015–16 | #9 Villanova | #7 Oklahoma | B12 | Neutral | L | 55–78 | Regular | Bloch Arena |
| 172 | 2015-12-13 | 2015–16 | #9 Villanova | La Salle | A10 | Home | W | 76–47 | Regular | Finneran Pavilion |
| 173 | 2015-12-19 | 2015–16 | #12 Villanova | #8 Virginia | ACC | Away | L | 75–86 | Regular | John Paul Jones Arena |
| 174 | 2016-01-06 | 2015–16 | #11 Villanova | Seton Hall | Big East | Home | W | 72–63 | Regular | Finneran Pavilion |
| 175 | 2016-01-10 | 2015–16 | #11 Villanova | #18 Butler | Big East | Away | W | 60–55 | Regular | Hinkle Fieldhouse |
| 176 | 2016-01-13 | 2015–16 | #6 Villanova | Marquette | Big East | Home | W | 83–68 | Regular | Finneran Pavilion |
| 177 | 2016-01-16 | 2015–16 | #6 Villanova | Georgetown | Big East | Away | W | 55–50 | Regular | Capital One Arena |
| 178 | 2016-01-20 | 2015–16 | #4 Villanova | Seton Hall | Big East | Away | W | 72–71 | Regular | Prudential Center |
| 179 | 2016-01-24 | 2015–16 | #4 Villanova | #16 Providence | Big East | Home | L | 76–82 OT | Regular | Xfinity Mobile Arena |
| 180 | 2016-01-31 | 2015–16 | #6 Villanova | St. John's (NY) | Big East | Away | W | 68–53 | Regular | Madison Square Garden |
| 181 | 2016-02-03 | 2015–16 | #3 Villanova | Creighton | Big East | Home | W | 83–58 | Regular | Finneran Pavilion |
| 182 | 2016-02-06 | 2015–16 | #3 Villanova | #11 Providence | Big East | Away | W | 72–60 | Regular | Amica Mutual Pavilion |
| 183 | 2016-02-09 | 2015–16 | #1 Villanova | DePaul | Big East | Away | W | 86–59 | Regular | Allstate Arena |
| 184 | 2016-02-13 | 2015–16 | #1 Villanova | St. John's (NY) | Big East | Home | W | 73–63 | Regular | Xfinity Mobile Arena |
| 185 | 2016-02-17 | 2015–16 | #1 Villanova | Temple | AAC | Away | W | 83–67 | Regular | Liacouras Center |
| 186 | 2016-02-20 | 2015–16 | #1 Villanova | Butler | Big East | Home | W | 77–67 | Regular | Finneran Pavilion |
| 187 | 2016-02-24 | 2015–16 | #1 Villanova | #5 Xavier | Big East | Away | L | 83–90 | Regular | Cintas Center |
| 188 | 2016-02-27 | 2015–16 | #1 Villanova | Marquette | Big East | Away | W | 89–79 | Regular | Bradley Center |
| 189 | 2016-03-01 | 2015–16 | #3 Villanova | DePaul | Big East | Home | W | 83–62 | Regular | Finneran Pavilion |
| 190 | 2016-03-05 | 2015–16 | #3 Villanova | Georgetown | Big East | Home | W | 84–71 | Regular | Finneran Pavilion |
| 191 | 2016-03-10 | 2015–16 | #3 Villanova | Georgetown | Big East | Neutral | W | 81–67 | Conf. Tourn. | Madison Square Garden |
| 192 | 2016-03-11 | 2015–16 | #3 Villanova | Providence | Big East | Neutral | W | 76–68 | Conf. Tourn. | Madison Square Garden |
| 193 | 2016-03-12 | 2015–16 | #3 Villanova | Seton Hall | Big East | Neutral | L | 67–69 | Conf. Tourn. | Madison Square Garden |
| 194 | 2016-11-11 | 2016–17 | #4 Villanova | Lafayette | Patriot | Home | W | 88–48 | Regular | Finneran Pavilion |
| 195 | 2016-11-14 | 2016–17 | #3 Villanova | #15 Purdue | B10 | Away | W | 79–76 | Regular | Mackey Arena |
| 196 | 2016-11-17 | 2016–17 | #3 Villanova | Western Michigan | MAC | Neutral | W | 76–65 | Regular | TD Arena |
| 197 | 2016-11-18 | 2016–17 | #3 Villanova | Wake Forest | ACC | Neutral | W | 96–77 | Regular | TD Arena |
| 198 | 2016-11-20 | 2016–17 | #3 Villanova | UCF | AAC | Neutral | W | 67–57 | Regular | TD Arena |
| 199 | 2016-11-23 | 2016–17 | #2 Villanova | College of Charleston | Colonial | Home | W | 63–47 | Regular | Finneran Pavilion |
| 200 | 2016-11-29 | 2016–17 | #2 Villanova | Pennsylvania | Ivy | Away | W | 82–57 | Regular | The Palestra |
| 201 | 2016-12-03 | 2016–17 | #2 Villanova | Saint Joseph's | A10 | Home | W | 88–57 | Regular | Finneran Pavilion |
| 202 | 2016-12-06 | 2016–17 | #1 Villanova | La Salle | A10 | Neutral | W | 89–79 | Regular | The Palestra |
| 203 | 2016-12-10 | 2016–17 | #1 Villanova | #23 Notre Dame | ACC | Neutral | W | 74–66 | Regular | Prudential Center |
| 204 | 2016-12-13 | 2016–17 | #1 Villanova | Temple | AAC | Home | W | 78–57 | Regular | Finneran Pavilion |
| 205 | 2016-12-21 | 2016–17 | #1 Villanova | American | Patriot | Home | W | 90–48 | Regular | Finneran Pavilion |
| 206 | 2016-12-28 | 2016–17 | #1 Villanova | DePaul | Big East | Home | W | 68–65 | Regular | Finneran Pavilion |
| 207 | 2016-12-31 | 2016–17 | #1 Villanova | #10 Creighton | Big East | Away | W | 80–70 | Regular | CHI Health Center Omaha |
| 208 | 2017-01-04 | 2016–17 | #1 Villanova | #18 Butler | Big East | Away | L | 58–66 | Regular | Hinkle Fieldhouse |
| 209 | 2017-01-07 | 2016–17 | #1 Villanova | Marquette | Big East | Home | W | 93–81 | Regular | Xfinity Mobile Arena |
| 210 | 2017-01-10 | 2016–17 | #3 Villanova | #15 Xavier | Big East | Home | W | 79–54 | Regular | Finneran Pavilion |
| 211 | 2017-01-14 | 2016–17 | #3 Villanova | St. John's (NY) | Big East | Away | W | 70–57 | Regular | Madison Square Garden |
| 212 | 2017-01-16 | 2016–17 | #1 Villanova | Seton Hall | Big East | Home | W | 76–46 | Regular | Finneran Pavilion |
| 213 | 2017-01-21 | 2016–17 | #1 Villanova | Providence | Big East | Home | W | 78–68 | Regular | Wells Fargo Arena |
| 214 | 2017-01-24 | 2016–17 | #1 Villanova | Marquette | Big East | Away | L | 72–74 | Regular | Bradley Center |
| 215 | 2017-01-29 | 2016–17 | #1 Villanova | #12 Virginia | ACC | Home | W | 61–59 | Regular | Finneran Pavilion |
| 216 | 2017-02-01 | 2016–17 | #4 Villanova | Providence | Big East | Away | W | 66–57 | Regular | Amica Mutual Pavilion |
| 217 | 2017-02-04 | 2016–17 | #4 Villanova | St. John's (NY) | Big East | Home | W | 92–79 | Regular | Xfinity Mobile Arena |
| 218 | 2017-02-07 | 2016–17 | #2 Villanova | Georgetown | Big East | Home | W | 75–64 | Regular | Finneran Pavilion |
| 219 | 2017-02-11 | 2016–17 | #2 Villanova | #24 Xavier | Big East | Away | W | 73–57 | Regular | Cintas Center |
| 220 | 2017-02-13 | 2016–17 | #2 Villanova | DePaul | Big East | Away | W | 75–62 | Regular | Allstate Arena |
| 221 | 2017-02-18 | 2016–17 | #2 Villanova | Seton Hall | Big East | Away | W | 92–70 | Regular | Prudential Center |
| 222 | 2017-02-22 | 2016–17 | #2 Villanova | #22 Butler | Big East | Home | L | 66–74 | Regular | Finneran Pavilion |
| 223 | 2017-02-25 | 2016–17 | #2 Villanova | #23 Creighton | Big East | Home | W | 79–63 | Regular | Finneran Pavilion |
| 224 | 2017-03-04 | 2016–17 | #2 Villanova | Georgetown | Big East | Away | W | 81–55 | Regular | Capital One Arena |
| 225 | 2017-03-09 | 2016–17 | #2 Villanova | St. John's (NY) | Big East | Neutral | W | 108–67 | Conf. Tourn. | Madison Square Garden |
| 226 | 2017-03-10 | 2016–17 | #2 Villanova | Seton Hall | Big East | Neutral | W | 55–53 | Conf. Tourn. | Madison Square Garden |
| 227 | 2017-03-11 | 2016–17 | #2 Villanova | Creighton | Big East | Neutral | W | 74–60 | Conf. Tourn. | Madison Square Garden |
| 228 | 2017-11-10 | 2017–18 | #6 Villanova | Columbia | Ivy | Home | W | 75–60 | Regular | Xfinity Mobile Arena |
| 229 | 2017-11-14 | 2017–18 | #5 Villanova | Nicholls State | Southland | Home | W | 113–77 | Regular | Xfinity Mobile Arena |
| 230 | 2017-11-17 | 2017–18 | #5 Villanova | Lafayette | Patriot | Neutral | W | 104–57 | Regular | PPL Center |
| 231 | 2017-11-22 | 2017–18 | #5 Villanova | Western Kentucky | CUSA | Neutral | W | 66–58 | Regular | Imperial Arena |
| 232 | 2017-11-23 | 2017–18 | #5 Villanova | Tennessee | SEC | Neutral | W | 85–76 | Regular | Imperial Arena |
| 233 | 2017-11-24 | 2017–18 | #5 Villanova | Northern Iowa | Missouri Valley | Neutral | W | 64–50 | Regular | Imperial Arena |
| 234 | 2017-11-29 | 2017–18 | #4 Villanova | Pennsylvania | Ivy | Home | W | 90–62 | Regular | Jake Nevin Field House |
| 235 | 2017-12-02 | 2017–18 | #4 Villanova | Saint Joseph's | A10 | Away | W | 94–53 | Regular | Hagan Arena |
| 236 | 2017-12-05 | 2017–18 | #4 Villanova | #12 Gonzaga | WCC | Neutral | W | 88–72 | Regular | Madison Square Garden |
| 237 | 2017-12-10 | 2017–18 | #4 Villanova | La Salle | A10 | Home | W | 77–68 | Regular | Xfinity Mobile Arena |
| 238 | 2017-12-13 | 2017–18 | #1 Villanova | Temple | AAC | Away | W | 87–67 | Regular | Liacouras Center |
| 239 | 2017-12-22 | 2017–18 | #1 Villanova | Hofstra | Colonial | Neutral | W | 95–71 | Regular | Nassau Coliseum |
| 240 | 2017-12-27 | 2017–18 | #1 Villanova | DePaul | Big East | Away | W | 103–85 | Regular | Wintrust Arena |
| 241 | 2017-12-30 | 2017–18 | #1 Villanova | Butler | Big East | Away | L | 93–101 | Regular | Hinkle Fieldhouse |
| 242 | 2018-01-06 | 2017–18 | #3 Villanova | Marquette | Big East | Home | W | 100–90 | Regular | Xfinity Mobile Arena |
| 243 | 2018-01-10 | 2017–18 | #1 Villanova | #10 Xavier | Big East | Home | W | 89–65 | Regular | Xfinity Mobile Arena |
| 244 | 2018-01-13 | 2017–18 | #1 Villanova | St. John's (NY) | Big East | Away | W | 78–71 | Regular | Madison Square Garden |
| 245 | 2018-01-17 | 2017–18 | #1 Villanova | Georgetown | Big East | Away | W | 88–56 | Regular | Capital One Arena |
| 246 | 2018-01-20 | 2017–18 | #1 Villanova | Connecticut | AAC | Away | W | 81–61 | Regular | PeoplesBank Arena |
| 247 | 2018-01-23 | 2017–18 | #1 Villanova | Providence | Big East | Home | W | 89–69 | Regular | Xfinity Mobile Arena |
| 248 | 2018-01-28 | 2017–18 | #1 Villanova | Marquette | Big East | Away | W | 85–82 | Regular | Bradley Center |
| 249 | 2018-02-01 | 2017–18 | #1 Villanova | Creighton | Big East | Home | W | 98–78 | Regular | Xfinity Mobile Arena |
| 250 | 2018-02-04 | 2017–18 | #1 Villanova | Seton Hall | Big East | Home | W | 92–76 | Regular | Xfinity Mobile Arena |
| 251 | 2018-02-07 | 2017–18 | #1 Villanova | St. John's (NY) | Big East | Home | L | 75–79 | Regular | Xfinity Mobile Arena |
| 252 | 2018-02-10 | 2017–18 | #1 Villanova | Butler | Big East | Home | W | 86–75 | Regular | Xfinity Mobile Arena |
| 253 | 2018-02-14 | 2017–18 | #3 Villanova | Providence | Big East | Away | L | 71–76 | Regular | Amica Mutual Pavilion |
| 254 | 2018-02-17 | 2017–18 | #3 Villanova | #4 Xavier | Big East | Away | W | 95–79 | Regular | Cintas Center |
| 255 | 2018-02-21 | 2017–18 | #3 Villanova | DePaul | Big East | Home | W | 93–62 | Regular | Xfinity Mobile Arena |
| 256 | 2018-02-24 | 2017–18 | #3 Villanova | Creighton | Big East | Away | L | 83–89 OT | Regular | CHI Health Center Omaha |
| 257 | 2018-02-28 | 2017–18 | #4 Villanova | Seton Hall | Big East | Away | W | 69–68 OT | Regular | Prudential Center |
| 258 | 2018-03-03 | 2017–18 | #4 Villanova | Georgetown | Big East | Home | W | 97–73 | Regular | Xfinity Mobile Arena |
| 259 | 2018-03-08 | 2017–18 | #2 Villanova | Marquette | Big East | Neutral | W | 94–70 | Conf. Tourn. | Madison Square Garden |
| 260 | 2018-03-09 | 2017–18 | #2 Villanova | Butler | Big East | Neutral | W | 87–68 | Conf. Tourn. | Madison Square Garden |
| 261 | 2018-03-10 | 2017–18 | #2 Villanova | Providence | Big East | Neutral | W | 76–66 OT | Conf. Tourn. | Madison Square Garden |
| 262 | 2018-11-06 | 2018–19 | #9 Villanova | Morgan State | MEAC | Home | W | 100–77 | Regular | Finneran Pavilion |
| 263 | 2018-11-10 | 2018–19 | #9 Villanova | Quinnipiac | MAAC | Home | W | 86–53 | Regular | Xfinity Mobile Arena |
| 264 | 2018-11-14 | 2018–19 | #8 Villanova | #18 Michigan | B10 | Home | L | 46–73 | Regular | Finneran Pavilion |
| 265 | 2018-11-17 | 2018–19 | #8 Villanova | Furman | SoCon | Home | L | 68–76 OT | Regular | Finneran Pavilion |
| 266 | 2018-11-22 | 2018–19 | #8 Villanova | Canisius | MAAC | Neutral | W | 83–56 | Regular | State Farm Field House |
| 267 | 2018-11-23 | 2018–19 | #8 Villanova | Oklahoma State | B12 | Neutral | W | 77–58 | Regular | State Farm Field House |
| 268 | 2018-11-25 | 2018–19 | #8 Villanova | #14 Florida State | ACC | Neutral | W | 66–60 | Regular | State Farm Field House |
| 269 | 2019-01-30 | 2018–19 | #14 Villanova | DePaul | Big East | Away | W | 86–74 | Regular | Wintrust Arena |
| 270 | 2019-02-03 | 2018–19 | #14 Villanova | Georgetown | Big East | Home | W | 77–65 | Regular | Xfinity Mobile Arena |
| 271 | 2019-02-06 | 2018–19 | #14 Villanova | Creighton | Big East | Home | W | 66–59 OT | Regular | Finneran Pavilion |
| 272 | 2019-02-09 | 2018–19 | #14 Villanova | #10 Marquette | Big East | Away | L | 65–66 | Regular | Fiserv Forum |
| 273 | 2019-02-13 | 2018–19 | #13 Villanova | Providence | Big East | Home | W | 85–67 | Regular | Finneran Pavilion |
| 274 | 2019-02-17 | 2018–19 | #13 Villanova | St. John's (NY) | Big East | Away | L | 65–71 | Regular | Madison Square Garden |
| 275 | 2019-11-05 | 2019–20 | #10 Villanova | Army | Patriot | Home | W | 97–54 | Regular | Finneran Pavilion |
| 276 | 2019-11-13 | 2019–20 | #10 Villanova | #16 Ohio State | B10 | Away | L | 51–76 | Regular | Value City Arena |
| 277 | 2019-11-16 | 2019–20 | #10 Villanova | Ohio | MAC | Home | W | 78–54 | Regular | Xfinity Mobile Arena |
| 278 | 2019-12-30 | 2019–20 | #10 Villanova | Xavier | Big East | Home | W | 68–62 | Regular | Finneran Pavilion |
| 279 | 2020-01-04 | 2019–20 | #10 Villanova | Marquette | Big East | Away | L | 60–71 | Regular | Fiserv Forum |
| 280 | 2020-01-14 | 2019–20 | #14 Villanova | DePaul | Big East | Home | W | 79–75 OT | Regular | Finneran Pavilion |
| 281 | 2020-01-18 | 2019–20 | #14 Villanova | Connecticut | AAC | Home | W | 61–55 | Regular | Xfinity Mobile Arena |
| 282 | 2020-01-21 | 2019–20 | #9 Villanova | #13 Butler | Big East | Home | W | 76–61 | Regular | Finneran Pavilion |
| 283 | 2020-01-25 | 2019–20 | #9 Villanova | Providence | Big East | Away | W | 64–60 | Regular | Amica Mutual Pavilion |
| 284 | 2020-01-28 | 2019–20 | #8 Villanova | St. John's (NY) | Big East | Away | W | 79–59 | Regular | Madison Square Garden |
| 285 | 2020-02-01 | 2019–20 | #8 Villanova | Creighton | Big East | Home | L | 61–76 | Regular | Xfinity Mobile Arena |
| 286 | 2020-02-05 | 2019–20 | #10 Villanova | #19 Butler | Big East | Away | L | 76–79 | Regular | Hinkle Fieldhouse |
| 287 | 2020-02-08 | 2019–20 | #10 Villanova | #12 Seton Hall | Big East | Home | L | 64–70 | Regular | Xfinity Mobile Arena |
| 288 | 2020-02-12 | 2019–20 | #15 Villanova | #18 Marquette | Big East | Home | W | 72–71 | Regular | Finneran Pavilion |
| 289 | 2020-02-16 | 2019–20 | #15 Villanova | Temple | AAC | Away | W | 76–56 | Regular | Liacouras Center |
| 290 | 2020-02-19 | 2019–20 | #12 Villanova | DePaul | Big East | Away | W | 91–71 | Regular | Wintrust Arena |
| 291 | 2020-02-22 | 2019–20 | #12 Villanova | Xavier | Big East | Away | W | 64–55 | Regular | Cintas Center |
| 292 | 2020-02-26 | 2019–20 | #12 Villanova | St. John's (NY) | Big East | Home | W | 71–60 | Regular | Finneran Pavilion |
| 293 | 2020-02-29 | 2019–20 | #12 Villanova | Providence | Big East | Home | L | 54–58 | Regular | Xfinity Mobile Arena |
| 294 | 2020-03-04 | 2019–20 | #14 Villanova | #8 Seton Hall | Big East | Away | W | 79–77 | Regular | Prudential Center |
| 295 | 2020-03-07 | 2019–20 | #14 Villanova | Georgetown | Big East | Away | W | 70–69 | Regular | Capital One Arena |
| 296 | 2020-11-25 | 2020–21 | #3 Villanova | Boston College | ACC | Neutral | W | 76–67 | Regular | Mohegan Sun Arena |
| 297 | 2020-11-26 | 2020–21 | #3 Villanova | #18 Arizona State | Pacific 12 | Neutral | W | 83–74 | Regular | Mohegan Sun Arena |
| 298 | 2020-11-28 | 2020–21 | #3 Villanova | Virginia Tech | ACC | Neutral | L | 73–81 OT | Regular | Mohegan Sun Arena |
| 299 | 2020-12-01 | 2020–21 | #12 Villanova | Hartford | Am. East | Neutral | W | 87–53 | Regular | Mohegan Sun Arena |
| 300 | 2020-12-06 | 2020–21 | #12 Villanova | #17 Texas | B12 | Away | W | 68–64 | Regular | Frank Erwin Center |
| 301 | 2020-12-11 | 2020–21 | #9 Villanova | Georgetown | Big East | Away | W | 76–63 | Regular | McDonough Gymnasium |
| 302 | 2020-12-16 | 2020–21 | #7 Villanova | Butler | Big East | Home | W | 85–66 | Regular | Finneran Pavilion |
| 303 | 2020-12-19 | 2020–21 | #7 Villanova | Saint Joseph's | A10 | Home | W | 88–68 | Regular | Finneran Pavilion |
| 304 | 2020-12-23 | 2020–21 | #5 Villanova | Marquette | Big East | Away | W | 85–68 | Regular | Fiserv Forum |
| 305 | 2021-01-19 | 2020–21 | #3 Villanova | Seton Hall | Big East | Home | W | 76–74 | Regular | Finneran Pavilion |
| 306 | 2021-01-23 | 2020–21 | #3 Villanova | Providence | Big East | Home | W | 71–56 | Regular | Finneran Pavilion |
| 307 | 2021-01-30 | 2020–21 | #3 Villanova | Seton Hall | Big East | Away | W | 80–72 | Regular | Prudential Center |
| 308 | 2021-02-03 | 2020–21 | #3 Villanova | St. John's (NY) | Big East | Away | L | 59–70 | Regular | Carnesecca Arena |
| 309 | 2021-02-07 | 2020–21 | #3 Villanova | Georgetown | Big East | Home | W | 84–74 | Regular | Finneran Pavilion |
| 310 | 2021-02-10 | 2020–21 | #5 Villanova | Marquette | Big East | Home | W | 96–64 | Regular | Finneran Pavilion |
| 311 | 2021-02-13 | 2020–21 | #5 Villanova | #19 Creighton | Big East | Away | L | 70–86 | Regular | CHI Health Center Omaha |
| 312 | 2021-02-20 | 2020–21 | #10 Villanova | Connecticut | Big East | Home | W | 68–60 | Regular | Finneran Pavilion |
| 313 | 2021-02-23 | 2020–21 | #8 Villanova | St. John's (NY) | Big East | Home | W | 81–58 | Regular | Finneran Pavilion |
| 314 | 2021-02-28 | 2020–21 | #8 Villanova | Butler | Big East | Away | L | 61–73 | Regular | Hinkle Fieldhouse |
| 315 | 2021-03-03 | 2020–21 | #10 Villanova | #14 Creighton | Big East | Home | W | 72–60 | Regular | Finneran Pavilion |
| 316 | 2021-03-06 | 2020–21 | #10 Villanova | Providence | Big East | Away | L | 52–54 | Regular | Mullaney Gymnasium |
| 317 | 2021-03-11 | 2020–21 | #14 Villanova | Georgetown | Big East | Neutral | L | 71–72 | Conf. Tourn. | Madison Square Garden |
| 318 | 2021-11-09 | 2021–22 | #4 Villanova | Mount St. Mary's | NEC | Home | W | 91–51 | Regular | Finneran Pavilion |
| 319 | 2021-11-12 | 2021–22 | #4 Villanova | #2 UCLA | Pacific 12 | Away | L | 77–86 OT | Regular | Pauley Pavilion |
| 320 | 2021-11-16 | 2021–22 | #5 Villanova | Howard | MEAC | Home | W | 100–81 | Regular | Finneran Pavilion |
| 321 | 2021-11-20 | 2021–22 | #5 Villanova | #17 Tennessee | SEC | Neutral | W | 71–53 | Regular | Mohegan Sun Arena |
| 322 | 2021-11-21 | 2021–22 | #5 Villanova | #6 Purdue | B10 | Neutral | L | 74–80 | Regular | Mohegan Sun Arena |
| 323 | 2021-11-28 | 2021–22 | #7 Villanova | La Salle | A10 | Neutral | W | 72–46 | Regular | The Palestra |
| 324 | 2021-12-01 | 2021–22 | #6 Villanova | Pennsylvania | Ivy | Away | W | 71–56 | Regular | The Palestra |
| 325 | 2021-12-04 | 2021–22 | #6 Villanova | Saint Joseph's | A10 | Home | W | 81–52 | Regular | Finneran Pavilion |
| 326 | 2021-12-07 | 2021–22 | #6 Villanova | Syracuse | ACC | Neutral | W | 67–53 | Regular | Madison Square Garden |
| 327 | 2021-12-12 | 2021–22 | #6 Villanova | #2 Baylor | B12 | Away | L | 36–57 | Regular | Ferrell Center |
| 328 | 2021-12-17 | 2021–22 | #9 Villanova | Creighton | Big East | Away | L | 59–79 | Regular | CHI Health Center Omaha |
| 329 | 2022-01-12 | 2021–22 | #14 Villanova | #17 Xavier | Big East | Away | W | 64–60 | Regular | Cintas Center |
| 330 | 2022-01-16 | 2021–22 | #14 Villanova | Butler | Big East | Home | W | 82–42 | Regular | Xfinity Mobile Arena |
| 331 | 2022-01-19 | 2021–22 | #11 Villanova | Marquette | Big East | Home | L | 54–57 | Regular | Finneran Pavilion |
| 332 | 2022-01-22 | 2021–22 | #11 Villanova | Georgetown | Big East | Away | W | 85–74 | Regular | Capital One Arena |
| 333 | 2022-01-25 | 2021–22 | #14 Villanova | DePaul | Big East | Home | W | 67–43 | Regular | Finneran Pavilion |
| 334 | 2022-01-29 | 2021–22 | #14 Villanova | St. John's (NY) | Big East | Home | W | 73–62 | Regular | Finneran Pavilion |
| 335 | 2022-02-02 | 2021–22 | #12 Villanova | #24 Marquette | Big East | Away | L | 73–83 | Regular | Fiserv Forum |
| 336 | 2022-02-05 | 2021–22 | #12 Villanova | #17 Connecticut | Big East | Home | W | 85–74 | Regular | Xfinity Mobile Arena |
| 337 | 2022-02-08 | 2021–22 | #15 Villanova | St. John's (NY) | Big East | Away | W | 75–69 | Regular | Madison Square Garden |
| 338 | 2022-02-12 | 2021–22 | #15 Villanova | Seton Hall | Big East | Home | W | 73–67 | Regular | Xfinity Mobile Arena |
| 339 | 2022-02-15 | 2021–22 | #10 Villanova | #8 Providence | Big East | Away | W | 89–84 | Regular | Amica Mutual Pavilion |
| 340 | 2022-02-19 | 2021–22 | #10 Villanova | Georgetown | Big East | Home | W | 74–66 | Regular | Finneran Pavilion |
| 341 | 2022-02-22 | 2021–22 | #8 Villanova | #21 Connecticut | Big East | Away | L | 69–71 | Regular | PeoplesBank Arena |
| 342 | 2022-03-01 | 2021–22 | #11 Villanova | #9 Providence | Big East | Home | W | 76–74 | Regular | Finneran Pavilion |
| 343 | 2022-03-05 | 2021–22 | #11 Villanova | Butler | Big East | Away | W | 78–59 | Regular | Hinkle Fieldhouse |
| 344 | 2022-03-10 | 2021–22 | #8 Villanova | St. John's (NY) | Big East | Neutral | W | 66–65 | Conf. Tourn. | Madison Square Garden |
| 345 | 2022-03-11 | 2021–22 | #8 Villanova | #20 Connecticut | Big East | Neutral | W | 63–60 | Conf. Tourn. | Madison Square Garden |
| 346 | 2022-03-12 | 2021–22 | #8 Villanova | Creighton | Big East | Neutral | W | 54–48 | Conf. Tourn. | Madison Square Garden |