Greg McDermott — Record When Unranked
at Creighton
109–58
65.3%
win rate
+6.6
avg margin
167
games
Games (167)
| # | Date | Season | School | Opponent | Opp. Conf. | Loc | W/L | Score | Type | Arena |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2010-11-12 | 2010–11 | Creighton | Alabama State | SWAC | Home | W | 71–57 | Regular | CHI Health Center Omaha |
| 2 | 2010-11-14 | 2010–11 | Creighton | Northern Arizona | Big Sky | Home | W | 74–70 | Regular | CHI Health Center Omaha |
| 3 | 2010-11-17 | 2010–11 | Creighton | Louisiana | Sun Belt | Home | W | 63–58 | Regular | CHI Health Center Omaha |
| 4 | 2010-11-21 | 2010–11 | Creighton | Iowa State | B12 | Neutral | L | 88–91 | Regular | Wells Fargo Arena |
| 5 | 2010-11-26 | 2010–11 | Creighton | Kennesaw State | ASUN | Home | W | 75–57 | Regular | CHI Health Center Omaha |
| 6 | 2010-11-28 | 2010–11 | Creighton | Northwestern | B10 | Away | L | 52–65 | Regular | Welsh–Ryan Arena |
| 7 | 2010-12-01 | 2010–11 | Creighton | #21 Brigham Young | Mountain West | Home | L | 65–77 | Regular | CHI Health Center Omaha |
| 8 | 2010-12-05 | 2010–11 | Creighton | Nebraska | B12 | Away | L | 54–59 | Regular | Bob Devaney Sports Center |
| 9 | 2010-12-11 | 2010–11 | Creighton | Saint Joseph's | A10 | Home | W | 82–75 | Regular | CHI Health Center Omaha |
| 10 | 2010-12-18 | 2010–11 | Creighton | Idaho State | Big Sky | Home | W | 66–60 | Regular | CHI Health Center Omaha |
| 11 | 2010-12-20 | 2010–11 | Creighton | Western Illinois | Summit | Home | W | 60–47 | Regular | CHI Health Center Omaha |
| 12 | 2010-12-22 | 2010–11 | Creighton | Samford | SoCon | Home | W | 58–40 | Regular | CHI Health Center Omaha |
| 13 | 2010-12-29 | 2010–11 | Creighton | Illinois State | Missouri Valley | Away | W | 64–53 | Regular | CEFCU Arena |
| 14 | 2011-01-01 | 2010–11 | Creighton | Drake | Missouri Valley | Home | W | 73–57 | Regular | CHI Health Center Omaha |
| 15 | 2011-01-04 | 2010–11 | Creighton | Missouri State | Missouri Valley | Home | L | 55–67 | Regular | CHI Health Center Omaha |
| 16 | 2011-01-07 | 2010–11 | Creighton | Southern Illinois | Missouri Valley | Away | W | 72–66 OT | Regular | SIU Arena |
| 17 | 2011-01-09 | 2010–11 | Creighton | Evansville | Missouri Valley | Away | W | 74–69 | Regular | Roberts Municipal Stadium |
| 18 | 2011-01-12 | 2010–11 | Creighton | Wichita State | Missouri Valley | Home | L | 54–68 | Regular | CHI Health Center Omaha |
| 19 | 2011-01-16 | 2010–11 | Creighton | Indiana State | Missouri Valley | Away | L | 59–61 | Regular | Hulman Center |
| 20 | 2011-01-19 | 2010–11 | Creighton | Bradley | Missouri Valley | Home | W | 81–68 | Regular | CHI Health Center Omaha |
| 21 | 2011-01-22 | 2010–11 | Creighton | Missouri State | Missouri Valley | Away | L | 66–67 | Regular | Great Southern Bank Arena |
| 22 | 2011-01-26 | 2010–11 | Creighton | Northern Iowa | Missouri Valley | Away | L | 66–71 | Regular | McLeod Center |
| 23 | 2011-01-29 | 2010–11 | Creighton | Indiana State | Missouri Valley | Home | W | 83–69 | Regular | CHI Health Center Omaha |
| 24 | 2011-02-01 | 2010–11 | Creighton | Bradley | Missouri Valley | Away | L | 61–69 | Regular | Carver Arena |
| 25 | 2011-02-05 | 2010–11 | Creighton | Evansville | Missouri Valley | Home | W | 75–69 | Regular | CHI Health Center Omaha |
| 26 | 2011-02-08 | 2010–11 | Creighton | Drake | Missouri Valley | Away | L | 64–67 | Regular | Knapp Center |
| 27 | 2011-02-13 | 2010–11 | Creighton | Southern Illinois | Missouri Valley | Home | W | 69–50 | Regular | CHI Health Center Omaha |
| 28 | 2011-02-16 | 2010–11 | Creighton | Illinois State | Missouri Valley | Home | W | 75–59 | Regular | CHI Health Center Omaha |
| 29 | 2011-02-19 | 2010–11 | Creighton | Akron | MAC | Away | L | 67–76 | Regular | James A. Rhodes Arena |
| 30 | 2011-02-23 | 2010–11 | Creighton | Wichita State | Missouri Valley | Away | L | 65–67 | Regular | Charles Koch Arena |
| 31 | 2011-02-26 | 2010–11 | Creighton | Northern Iowa | Missouri Valley | Home | W | 63–55 | Regular | CHI Health Center Omaha |
| 32 | 2011-03-04 | 2010–11 | Creighton | Northern Iowa | Missouri Valley | Neutral | W | 60–57 | Conf. Tourn. | Enterprise Center |
| 33 | 2011-03-05 | 2010–11 | Creighton | Missouri State | Missouri Valley | Neutral | L | 50–60 | Conf. Tourn. | Enterprise Center |
| 34 | 2011-11-11 | 2011–12 | Creighton | North Carolina A&T | MEAC | Home | W | 97–65 | Regular | CHI Health Center Omaha |
| 35 | 2011-11-13 | 2011–12 | Creighton | Chicago State | Great West | Home | W | 95–61 | Regular | CHI Health Center Omaha |
| 36 | 2011-11-16 | 2011–12 | Creighton | UAB | CUSA | Away | W | 70–60 | Regular | Bartow Arena |
| 37 | 2011-11-20 | 2011–12 | Creighton | Iowa | B10 | Neutral | W | 82–59 | Regular | Wells Fargo Arena |
| 38 | 2011-11-25 | 2011–12 | Creighton | Campbell | Big South | Home | W | 104–81 | Regular | CHI Health Center Omaha |
| 39 | 2011-11-30 | 2011–12 | Creighton | San Diego State | Mountain West | Away | W | 85–83 | Regular | Viejas Arena |
| 40 | 2011-12-04 | 2011–12 | Creighton | Nebraska | B10 | Home | W | 76–66 | Regular | CHI Health Center Omaha |
| 41 | 2013-11-08 | 2013–14 | Creighton | Alcorn State | SWAC | Home | W | 107–61 | Regular | CHI Health Center Omaha |
| 42 | 2013-11-11 | 2013–14 | Creighton | Kansas City | WAC | Home | W | 96–70 | Regular | CHI Health Center Omaha |
| 43 | 2013-11-16 | 2013–14 | Creighton | Saint Joseph's | A10 | Away | W | 83–79 | Regular | Hagan Arena |
| 44 | 2014-11-14 | 2014–15 | Creighton | Central Arkansas | Southland | Home | W | 104–77 | Regular | CHI Health Center Omaha |
| 45 | 2014-11-16 | 2014–15 | Creighton | Chicago State | WAC | Home | W | 84–66 | Regular | CHI Health Center Omaha |
| 46 | 2014-11-19 | 2014–15 | Creighton | #18 Oklahoma | B12 | Home | W | 65–63 | Regular | CHI Health Center Omaha |
| 47 | 2014-11-23 | 2014–15 | Creighton | North Carolina Central | MEAC | Home | W | 65–45 | Regular | CHI Health Center Omaha |
| 48 | 2015-11-14 | 2015–16 | Creighton | Texas Southern | SWAC | Home | W | 93–70 | Regular | CHI Health Center Omaha |
| 49 | 2015-11-17 | 2015–16 | Creighton | UTSA | CUSA | Home | W | 103–78 | Regular | CHI Health Center Omaha |
| 50 | 2015-11-19 | 2015–16 | Creighton | #14 Indiana | B10 | Away | L | 65–86 | Regular | Simon Skjodt Assembly Hall |
| 51 | 2015-11-23 | 2015–16 | Creighton | Rutgers | B10 | Neutral | W | 85–75 | Regular | MGM Grand Garden Arena |
| 52 | 2015-11-25 | 2015–16 | Creighton | Massachusetts | A10 | Neutral | W | 97–76 | Regular | MGM Grand Garden Arena |
| 53 | 2015-11-28 | 2015–16 | Creighton | Western Illinois | Summit | Home | W | 97–67 | Regular | CHI Health Center Omaha |
| 54 | 2015-12-02 | 2015–16 | Creighton | Arizona State | Pacific 12 | Home | L | 77–79 | Regular | CHI Health Center Omaha |
| 55 | 2015-12-05 | 2015–16 | Creighton | Loyola (IL) | Missouri Valley | Away | L | 65–68 | Regular | Joseph J. Gentile Arena |
| 56 | 2015-12-09 | 2015–16 | Creighton | Nebraska | B10 | Home | W | 83–67 | Regular | CHI Health Center Omaha |
| 57 | 2015-12-12 | 2015–16 | Creighton | IU Indy | Summit | Home | W | 90–65 | Regular | CHI Health Center Omaha |
| 58 | 2015-12-19 | 2015–16 | Creighton | #3 Oklahoma | B12 | Away | L | 74–87 | Regular | Lloyd Noble Center |
| 59 | 2015-12-21 | 2015–16 | Creighton | North Texas | CUSA | Home | W | 105–82 | Regular | CHI Health Center Omaha |
| 60 | 2015-12-28 | 2015–16 | Creighton | Coppin State | MEAC | Home | W | 102–77 | Regular | CHI Health Center Omaha |
| 61 | 2015-12-31 | 2015–16 | Creighton | St. John's (NY) | Big East | Away | W | 80–70 | Regular | Carnesecca Arena |
| 62 | 2016-01-02 | 2015–16 | Creighton | #16 Villanova | Big East | Home | L | 71–85 | Regular | CHI Health Center Omaha |
| 63 | 2016-01-05 | 2015–16 | Creighton | Georgetown | Big East | Home | W | 79–66 | Regular | CHI Health Center Omaha |
| 64 | 2016-01-09 | 2015–16 | Creighton | Seton Hall | Big East | Away | W | 82–67 | Regular | Prudential Center |
| 65 | 2016-01-12 | 2015–16 | Creighton | #12 Providence | Big East | Home | L | 48–50 | Regular | CHI Health Center Omaha |
| 66 | 2016-01-17 | 2015–16 | Creighton | DePaul | Big East | Away | W | 91–80 | Regular | Allstate Arena |
| 67 | 2016-01-23 | 2015–16 | Creighton | #18 Butler | Big East | Home | W | 72–64 | Regular | CHI Health Center Omaha |
| 68 | 2016-01-26 | 2015–16 | Creighton | Georgetown | Big East | Away | L | 73–74 | Regular | Capital One Arena |
| 69 | 2016-01-30 | 2015–16 | Creighton | Seton Hall | Big East | Home | L | 65–75 | Regular | CHI Health Center Omaha |
| 70 | 2016-02-03 | 2015–16 | Creighton | #3 Villanova | Big East | Away | L | 58–83 | Regular | Finneran Pavilion |
| 71 | 2016-02-06 | 2015–16 | Creighton | DePaul | Big East | Home | W | 88–66 | Regular | CHI Health Center Omaha |
| 72 | 2016-02-09 | 2015–16 | Creighton | #5 Xavier | Big East | Home | W | 70–56 | Regular | CHI Health Center Omaha |
| 73 | 2016-02-13 | 2015–16 | Creighton | Marquette | Big East | Away | W | 65–62 | Regular | Bradley Center |
| 74 | 2016-02-16 | 2015–16 | Creighton | Butler | Big East | Away | L | 75–88 | Regular | Hinkle Fieldhouse |
| 75 | 2016-02-24 | 2015–16 | Creighton | Marquette | Big East | Home | L | 61–66 | Regular | CHI Health Center Omaha |
| 76 | 2016-02-28 | 2015–16 | Creighton | St. John's (NY) | Big East | Home | W | 100–59 | Regular | CHI Health Center Omaha |
| 77 | 2016-03-02 | 2015–16 | Creighton | Providence | Big East | Away | L | 66–70 | Regular | Amica Mutual Pavilion |
| 78 | 2016-03-05 | 2015–16 | Creighton | #5 Xavier | Big East | Away | L | 93–98 | Regular | Cintas Center |
| 79 | 2016-03-10 | 2015–16 | Creighton | Seton Hall | Big East | Neutral | L | 73–81 | Conf. Tourn. | Madison Square Garden |
| 80 | 2017-11-10 | 2017–18 | Creighton | Yale | Ivy | Home | W | 92–76 | Regular | CHI Health Center Omaha |
| 81 | 2017-11-12 | 2017–18 | Creighton | Alcorn State | SWAC | Home | W | 109–72 | Regular | CHI Health Center Omaha |
| 82 | 2017-11-15 | 2017–18 | Creighton | #20 Northwestern | B10 | Away | W | 92–88 | Regular | Allstate Arena |
| 83 | 2017-11-20 | 2017–18 | Creighton | #24 UCLA | Pacific 12 | Neutral | W | 100–89 | Regular | T-Mobile Center |
| 84 | 2017-11-21 | 2017–18 | Creighton | #22 Baylor | B12 | Neutral | L | 59–65 | Regular | T-Mobile Center |
| 85 | 2017-11-25 | 2017–18 | Creighton | Southern Illinois-Edwardsville | OVC | Home | W | 103–66 | Regular | CHI Health Center Omaha |
| 86 | 2018-11-06 | 2018–19 | Creighton | Western Illinois | Summit | Home | W | 78–67 | Regular | CHI Health Center Omaha |
| 87 | 2018-11-11 | 2018–19 | Creighton | East Tennessee State | SoCon | Home | W | 75–69 | Regular | CHI Health Center Omaha |
| 88 | 2018-11-15 | 2018–19 | Creighton | Ohio State | B10 | Home | L | 60–69 | Regular | CHI Health Center Omaha |
| 89 | 2018-11-19 | 2018–19 | Creighton | Boise State | Mountain West | Neutral | W | 94–82 | Regular | John Gray Gymnasium |
| 90 | 2018-11-20 | 2018–19 | Creighton | Georgia State | Sun Belt | Neutral | W | 93–68 | Regular | John Gray Gymnasium |
| 91 | 2018-11-21 | 2018–19 | Creighton | #16 Clemson | ACC | Neutral | W | 87–82 | Regular | John Gray Gymnasium |
| 92 | 2018-11-28 | 2018–19 | Creighton | Montana | Big Sky | Home | W | 98–72 | Regular | CHI Health Center Omaha |
| 93 | 2018-12-01 | 2018–19 | Creighton | #1 Gonzaga | WCC | Home | L | 92–103 | Regular | CHI Health Center Omaha |
| 94 | 2018-12-08 | 2018–19 | Creighton | #24 Nebraska | B10 | Away | L | 75–94 | Regular | Pinnacle Bank Arena |
| 95 | 2018-12-14 | 2018–19 | Creighton | Green Bay | Horizon | Home | W | 86–65 | Regular | CHI Health Center Omaha |
| 96 | 2018-12-18 | 2018–19 | Creighton | Oklahoma | B12 | Away | L | 70–83 | Regular | Lloyd Noble Center |
| 97 | 2018-12-20 | 2018–19 | Creighton | Coe | - | Home | W | 110–60 | Regular | CHI Health Center Omaha |
| 98 | 2018-12-27 | 2018–19 | Creighton | Kansas City | WAC | Home | W | 89–53 | Regular | CHI Health Center Omaha |
| 99 | 2018-12-31 | 2018–19 | Creighton | Providence | Big East | Away | W | 79–68 | Regular | Amica Mutual Pavilion |
| 100 | 2019-01-05 | 2018–19 | Creighton | Butler | Big East | Away | L | 69–84 | Regular | Hinkle Fieldhouse |
| 101 | 2019-01-09 | 2018–19 | Creighton | #21 Marquette | Big East | Home | L | 104–106 OT | Regular | CHI Health Center Omaha |
| 102 | 2019-01-13 | 2018–19 | Creighton | Villanova | Big East | Home | L | 78–90 | Regular | CHI Health Center Omaha |
| 103 | 2019-01-16 | 2018–19 | Creighton | St. John's (NY) | Big East | Away | L | 66–81 | Regular | Carnesecca Arena |
| 104 | 2019-01-21 | 2018–19 | Creighton | Georgetown | Big East | Away | W | 91–87 | Regular | Capital One Arena |
| 105 | 2019-01-25 | 2018–19 | Creighton | Butler | Big East | Home | W | 75–61 | Regular | CHI Health Center Omaha |
| 106 | 2019-01-30 | 2018–19 | Creighton | St. John's (NY) | Big East | Home | L | 67–83 | Regular | CHI Health Center Omaha |
| 107 | 2019-02-03 | 2018–19 | Creighton | Xavier | Big East | Home | W | 76–54 | Regular | CHI Health Center Omaha |
| 108 | 2019-02-06 | 2018–19 | Creighton | #14 Villanova | Big East | Away | L | 59–66 OT | Regular | Finneran Pavilion |
| 109 | 2019-02-09 | 2018–19 | Creighton | Seton Hall | Big East | Away | L | 58–63 | Regular | Prudential Center |
| 110 | 2019-02-13 | 2018–19 | Creighton | Xavier | Big East | Away | L | 61–64 OT | Regular | Cintas Center |
| 111 | 2019-02-17 | 2018–19 | Creighton | Seton Hall | Big East | Home | L | 75–81 | Regular | CHI Health Center Omaha |
| 112 | 2019-02-20 | 2018–19 | Creighton | DePaul | Big East | Away | W | 79–67 | Regular | Wintrust Arena |
| 113 | 2019-02-23 | 2018–19 | Creighton | Georgetown | Big East | Home | W | 82–69 | Regular | CHI Health Center Omaha |
| 114 | 2019-03-03 | 2018–19 | Creighton | #10 Marquette | Big East | Away | W | 66–60 | Regular | Fiserv Forum |
| 115 | 2019-03-06 | 2018–19 | Creighton | Providence | Big East | Home | W | 76–70 OT | Regular | CHI Health Center Omaha |
| 116 | 2019-03-09 | 2018–19 | Creighton | DePaul | Big East | Home | W | 91–78 | Regular | CHI Health Center Omaha |
| 117 | 2019-03-14 | 2018–19 | Creighton | Xavier | Big East | Neutral | L | 61–63 | Conf. Tourn. | Madison Square Garden |
| 118 | 2019-11-05 | 2019–20 | Creighton | Kennesaw State | ASUN | Home | W | 81–55 | Regular | CHI Health Center Omaha |
| 119 | 2019-11-12 | 2019–20 | Creighton | Michigan | B10 | Away | L | 69–79 | Regular | Crisler Center |
| 120 | 2019-11-16 | 2019–20 | Creighton | Louisiana Tech | CUSA | Home | W | 82–72 | Regular | CHI Health Center Omaha |
| 121 | 2019-11-22 | 2019–20 | Creighton | Cal Poly | Big West | Home | W | 86–70 | Regular | CHI Health Center Omaha |
| 122 | 2019-11-24 | 2019–20 | Creighton | North Florida | ASUN | Home | W | 76–67 | Regular | CHI Health Center Omaha |
| 123 | 2019-11-28 | 2019–20 | Creighton | San Diego State | Mountain West | Neutral | L | 52–83 | Regular | Orleans Arena |
| 124 | 2019-11-29 | 2019–20 | Creighton | #12 Texas Tech | B12 | Neutral | W | 83–76 OT | Regular | Orleans Arena |
| 125 | 2019-12-03 | 2019–20 | Creighton | Oral Roberts | Summit | Home | W | 72–60 | Regular | CHI Health Center Omaha |
| 126 | 2019-12-07 | 2019–20 | Creighton | Nebraska | B10 | Home | W | 95–76 | Regular | CHI Health Center Omaha |
| 127 | 2019-12-13 | 2019–20 | Creighton | Texas-Rio Grande Valley | WAC | Home | W | 89–58 | Regular | CHI Health Center Omaha |
| 128 | 2019-12-17 | 2019–20 | Creighton | Oklahoma | B12 | Home | W | 83–73 | Regular | CHI Health Center Omaha |
| 129 | 2019-12-21 | 2019–20 | Creighton | Arizona State | Pacific 12 | Away | W | 67–60 | Regular | Desert Financial Arena |
| 130 | 2019-12-28 | 2019–20 | Creighton | Midland Lutheran | - | Home | W | 91–54 | Regular | CHI Health Center Omaha |
| 131 | 2020-01-01 | 2019–20 | Creighton | Marquette | Big East | Home | W | 92–75 | Regular | CHI Health Center Omaha |
| 132 | 2020-01-04 | 2019–20 | Creighton | #11 Butler | Big East | Away | L | 57–71 | Regular | Hinkle Fieldhouse |
| 133 | 2020-01-07 | 2019–20 | Creighton | #16 Villanova | Big East | Home | L | 59–64 | Regular | CHI Health Center Omaha |
| 134 | 2020-01-11 | 2019–20 | Creighton | Xavier | Big East | Away | W | 77–65 | Regular | Cintas Center |
| 135 | 2021-11-09 | 2021–22 | Creighton | Arkansas-Pine Bluff | SWAC | Home | W | 90–77 | Regular | CHI Health Center Omaha |
| 136 | 2021-11-11 | 2021–22 | Creighton | Kennesaw State | ASUN | Home | W | 51–44 | Regular | CHI Health Center Omaha |
| 137 | 2021-11-16 | 2021–22 | Creighton | Nebraska | B10 | Away | W | 77–69 | Regular | Pinnacle Bank Arena |
| 138 | 2021-11-19 | 2021–22 | Creighton | Brown | Ivy | Neutral | W | 78–57 | Regular | UVI Sports and Fitness Center |
| 139 | 2021-11-21 | 2021–22 | Creighton | Colorado State | Mountain West | Neutral | L | 81–95 | Regular | UVI Sports and Fitness Center |
| 140 | 2021-11-22 | 2021–22 | Creighton | Southern Illinois | Missouri Valley | Neutral | W | 66–64 | Regular | UVI Sports and Fitness Center |
| 141 | 2021-11-27 | 2021–22 | Creighton | Southern Illinois-Edwardsville | OVC | Home | W | 70–65 | Regular | CHI Health Center Omaha |
| 142 | 2021-11-30 | 2021–22 | Creighton | North Dakota State | Summit | Home | W | 80–55 | Regular | CHI Health Center Omaha |
| 143 | 2021-12-04 | 2021–22 | Creighton | #19 Iowa State | B12 | Home | L | 58–64 | Regular | CHI Health Center Omaha |
| 144 | 2021-12-11 | 2021–22 | Creighton | #24 Brigham Young | WCC | Neutral | W | 83–71 | Regular | Sanford Pentagon |
| 145 | 2021-12-14 | 2021–22 | Creighton | Arizona State | Pacific 12 | Home | L | 57–58 | Regular | CHI Health Center Omaha |
| 146 | 2021-12-17 | 2021–22 | Creighton | #9 Villanova | Big East | Home | W | 79–59 | Regular | CHI Health Center Omaha |
| 147 | 2022-01-01 | 2021–22 | Creighton | Marquette | Big East | Away | W | 75–69 2OT | Regular | Fiserv Forum |
| 148 | 2022-01-05 | 2021–22 | Creighton | #19 Villanova | Big East | Away | L | 41–75 | Regular | Finneran Pavilion |
| 149 | 2022-01-15 | 2021–22 | Creighton | #17 Xavier | Big East | Away | L | 73–80 | Regular | Cintas Center |
| 150 | 2022-01-19 | 2021–22 | Creighton | St. John's (NY) | Big East | Home | W | 87–64 | Regular | CHI Health Center Omaha |
| 151 | 2022-01-22 | 2021–22 | Creighton | DePaul | Big East | Home | W | 60–47 | Regular | CHI Health Center Omaha |
| 152 | 2022-01-26 | 2021–22 | Creighton | Butler | Big East | Away | L | 55–72 | Regular | Hinkle Fieldhouse |
| 153 | 2022-01-29 | 2021–22 | Creighton | #21 Xavier | Big East | Home | L | 64–74 | Regular | CHI Health Center Omaha |
| 154 | 2022-02-01 | 2021–22 | Creighton | #17 Connecticut | Big East | Away | W | 59–55 | Regular | PeoplesBank Arena |
| 155 | 2022-02-04 | 2021–22 | Creighton | Seton Hall | Big East | Away | L | 55–74 | Regular | Prudential Center |
| 156 | 2022-02-08 | 2021–22 | Creighton | Butler | Big East | Home | W | 54–52 | Regular | CHI Health Center Omaha |
| 157 | 2022-02-12 | 2021–22 | Creighton | Georgetown | Big East | Away | W | 80–66 | Regular | Capital One Arena |
| 158 | 2022-02-14 | 2021–22 | Creighton | Georgetown | Big East | Home | W | 88–77 | Regular | CHI Health Center Omaha |
| 159 | 2022-02-17 | 2021–22 | Creighton | DePaul | Big East | Away | W | 71–59 | Regular | Wintrust Arena |
| 160 | 2022-02-20 | 2021–22 | Creighton | Marquette | Big East | Home | W | 83–82 | Regular | CHI Health Center Omaha |
| 161 | 2022-02-23 | 2021–22 | Creighton | St. John's (NY) | Big East | Away | W | 81–78 | Regular | Carnesecca Arena |
| 162 | 2022-02-26 | 2021–22 | Creighton | #11 Providence | Big East | Away | L | 51–72 | Regular | Amica Mutual Pavilion |
| 163 | 2022-03-02 | 2021–22 | Creighton | #18 Connecticut | Big East | Home | W | 64–62 | Regular | CHI Health Center Omaha |
| 164 | 2022-03-05 | 2021–22 | Creighton | Seton Hall | Big East | Home | L | 60–65 | Regular | CHI Health Center Omaha |
| 165 | 2022-03-10 | 2021–22 | Creighton | Marquette | Big East | Neutral | W | 74–63 | Conf. Tourn. | Madison Square Garden |
| 166 | 2022-03-11 | 2021–22 | Creighton | #11 Providence | Big East | Neutral | W | 85–58 | Conf. Tourn. | Madison Square Garden |
| 167 | 2022-03-12 | 2021–22 | Creighton | #8 Villanova | Big East | Neutral | L | 48–54 | Conf. Tourn. | Madison Square Garden |