DePaul 2020–21
Coach: Dave Leitao (5-14)
Big East Conference
5-14
overall
4-13
regular season
2-13
in conference
Games (19)
| # | Date | School | Opponent | Opp. Conf. | Loc | W/L | Score | Type | Arena |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2020-12-23 | DePaul | Western Illinois | Summit | Home | W | 91–72 | Regular | Wintrust Arena |
| 2 | 2020-12-27 | DePaul | Providence | Big East | Away | L | 90–95 2OT | Regular | Mullaney Gymnasium |
| 3 | 2020-12-30 | DePaul | Connecticut | Big East | Away | L | 61–82 | Regular | Harry A. Gampel Pavilion |
| 4 | 2021-01-09 | DePaul | Seton Hall | Big East | Home | L | 68–76 | Regular | Wintrust Arena |
| 5 | 2021-01-11 | DePaul | #25 Connecticut | Big East | Home | L | 53–60 | Regular | Wintrust Arena |
| 6 | 2021-01-16 | DePaul | Valparaiso | Missouri Valley | Home | W | 77–58 | Regular | Wintrust Arena |
| 7 | 2021-01-19 | DePaul | Butler | Big East | Home | L | 53–67 | Regular | Wintrust Arena |
| 8 | 2021-01-23 | DePaul | Marquette | Big East | Away | W | 68–61 | Regular | Fiserv Forum |
| 9 | 2021-01-27 | DePaul | St. John's (NY) | Big East | Home | L | 68–81 | Regular | Wintrust Arena |
| 10 | 2021-01-30 | DePaul | #17 Creighton | Big East | Home | L | 62–69 | Regular | Wintrust Arena |
| 11 | 2021-02-06 | DePaul | Butler | Big East | Away | L | 58–68 | Regular | Hinkle Fieldhouse |
| 12 | 2021-02-13 | DePaul | Providence | Big East | Home | L | 47–57 | Regular | Wintrust Arena |
| 13 | 2021-02-17 | DePaul | Seton Hall | Big East | Away | L | 52–60 | Regular | Prudential Center |
| 14 | 2021-02-20 | DePaul | St. John's (NY) | Big East | Away | W | 88–83 | Regular | Carnesecca Arena |
| 15 | 2021-02-24 | DePaul | #13 Creighton | Big East | Away | L | 53–77 | Regular | CHI Health Center Omaha |
| 16 | 2021-02-27 | DePaul | Georgetown | Big East | Home | L | 60–68 | Regular | Wintrust Arena |
| 17 | 2021-03-02 | DePaul | Marquette | Big East | Home | L | 71–77 | Regular | Wintrust Arena |
| 18 | 2021-03-10 | DePaul | Providence | Big East | Neutral | W | 70–62 | Conf. Tourn. | Madison Square Garden |
| 19 | 2021-03-11 | DePaul | Connecticut | Big East | Neutral | L | 60–94 | Conf. Tourn. | Madison Square Garden |