Louisville 2021–22
Coach: Chris Mack (6-8), Coach: Mike Pegues (7-11)
Atlantic Coast Conference
13-19
overall
12-18
regular season
6-14
in conference
Games (32)
| # | Date | School | Opponent | Opp. Conf. | Loc | W/L | Score | Type | Arena |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Louisville | Southern | SWAC | Home | W | 72–60 | Regular | KFC Yum! Center |
| 2 | 2021-11-12 | Louisville | Furman | SoCon | Home | L | 72–80 OT | Regular | KFC Yum! Center |
| 3 | 2021-11-15 | Louisville | Navy | Patriot | Home | W | 77–60 | Regular | KFC Yum! Center |
| 4 | 2021-11-20 | Louisville | Detroit Mercy | Horizon | Home | W | 73–67 | Regular | KFC Yum! Center |
| 5 | 2021-11-25 | Louisville | Mississippi State | SEC | Neutral | W | 72–58 | Regular | Baha Mar Convention Center |
| 6 | 2021-11-27 | Louisville | Maryland | B10 | Neutral | W | 63–55 | Regular | Baha Mar Convention Center |
| 7 | 2021-12-01 | Louisville | #22 Michigan State | B10 | Away | L | 64–73 | Regular | Breslin Events Center |
| 8 | 2021-12-04 | Louisville | NC State | ACC | Away | W | 73–68 | Regular | Lenovo Center |
| 9 | 2021-12-10 | Louisville | DePaul | Big East | Home | L | 55–62 | Regular | KFC Yum! Center |
| 10 | 2021-12-14 | Louisville | Southeastern Louisiana | Southland | Home | W | 86–60 | Regular | KFC Yum! Center |
| 11 | 2021-12-18 | Louisville | Western Kentucky | CUSA | Away | L | 72–82 | Regular | E. A. Diddle Arena |
| 12 | 2021-12-29 | Louisville | Wake Forest | ACC | Home | W | 73–69 | Regular | KFC Yum! Center |
| 13 | 2022-01-02 | Louisville | Georgia Tech | ACC | Away | W | 67–64 | Regular | McCamish Pavilion |
| 14 | 2022-01-05 | Louisville | Pittsburgh | ACC | Home | W | 75–72 | Regular | KFC Yum! Center |
| 15 | 2022-01-08 | Louisville | Florida State | ACC | Away | L | 70–79 | Regular | Donald L. Tucker Civic Center |
| 16 | 2022-01-12 | Louisville | NC State | ACC | Home | L | 63–79 | Regular | KFC Yum! Center |
| 17 | 2022-01-15 | Louisville | Pittsburgh | ACC | Away | L | 53–65 | Regular | Petersen Events Center |
| 18 | 2022-01-19 | Louisville | Boston College | ACC | Home | W | 67–54 | Regular | KFC Yum! Center |
| 19 | 2022-01-22 | Louisville | Notre Dame | ACC | Home | L | 70–82 | Regular | KFC Yum! Center |
| 20 | 2022-01-24 | Louisville | Virginia | ACC | Away | L | 52–64 | Regular | John Paul Jones Arena |
| 21 | 2022-01-29 | Louisville | #9 Duke | ACC | Home | L | 65–74 | Regular | KFC Yum! Center |
| 22 | 2022-02-01 | Louisville | North Carolina | ACC | Home | L | 83–90 OT | Regular | KFC Yum! Center |
| 23 | 2022-02-05 | Louisville | Syracuse | ACC | Away | L | 69–92 | Regular | Carrier Dome |
| 24 | 2022-02-09 | Louisville | Notre Dame | ACC | Away | L | 57–63 | Regular | Purcell Pavilion |
| 25 | 2022-02-16 | Louisville | Miami (FL) | ACC | Home | L | 63–70 | Regular | KFC Yum! Center |
| 26 | 2022-02-19 | Louisville | Clemson | ACC | Home | W | 70–61 | Regular | KFC Yum! Center |
| 27 | 2022-02-21 | Louisville | North Carolina | ACC | Away | L | 63–70 | Regular | Dean Smith Center |
| 28 | 2022-02-26 | Louisville | Wake Forest | ACC | Away | L | 77–99 | Regular | Lawrence Joel Veterans Memorial Coliseum |
| 29 | 2022-03-01 | Louisville | Virginia Tech | ACC | Away | L | 43–75 | Regular | Cassell Coliseum |
| 30 | 2022-03-05 | Louisville | Virginia | ACC | Home | L | 61–71 | Regular | KFC Yum! Center |
| 31 | 2022-03-08 | Louisville | Georgia Tech | ACC | Neutral | W | 84–74 | Conf. Tourn. | Barclays Center |
| 32 | 2022-03-09 | Louisville | Virginia | ACC | Neutral | L | 50–51 | Conf. Tourn. | Barclays Center |