Chris Mack — Regular Season Record
256–113
69.4%
win rate
+6.5
avg margin
369
games
Games (369)
| # | Date | Season | School | Opponent | Opp. Conf. | Loc | W/L | Score | Type | Arena |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2009-11-13 | 2009–10 | Xavier | Youngstown State | Horizon | Home | W | 83–57 | Regular | Cintas Center |
| 2 | 2009-11-17 | 2009–10 | Xavier | Bowling Green | MAC | Home | W | 101–57 | Regular | Cintas Center |
| 3 | 2009-11-21 | 2009–10 | Xavier | Sacred Heart | NEC | Home | W | 105–65 | Regular | Cintas Center |
| 4 | 2009-11-26 | 2009–10 | Xavier | Marquette | Big East | Neutral | L | 61–71 | Regular | State Farm Field House |
| 5 | 2009-11-27 | 2009–10 | Xavier | Creighton | Missouri Valley | Neutral | W | 80–67 | Regular | State Farm Field House |
| 6 | 2009-11-29 | 2009–10 | Xavier | Baylor | B12 | Neutral | L | 64–69 | Regular | State Farm Field House |
| 7 | 2009-12-04 | 2009–10 | Xavier | Kent State | MAC | Home | W | 77–61 | Regular | Cintas Center |
| 8 | 2009-12-08 | 2009–10 | Xavier | Kansas State | B12 | Away | L | 56–71 | Regular | Bramlage Coliseum |
| 9 | 2009-12-13 | 2009–10 | Xavier | #19 Cincinnati | Big East | Home | W | 83–79 2OT | Regular | Cintas Center |
| 10 | 2009-12-19 | 2009–10 | Xavier | #21 Butler | Horizon | Away | L | 68–69 | Regular | Hinkle Fieldhouse |
| 11 | 2009-12-23 | 2009–10 | Xavier | Miami (OH) | MAC | Home | W | 70–67 | Regular | Cintas Center |
| 12 | 2009-12-29 | 2009–10 | Xavier | Louisiana State | SEC | Home | W | 89–65 | Regular | Cintas Center |
| 13 | 2010-01-03 | 2009–10 | Xavier | Wake Forest | ACC | Away | L | 92–96 2OT | Regular | Lawrence Joel Veterans Memorial Coliseum |
| 14 | 2010-01-07 | 2009–10 | Xavier | La Salle | A10 | Away | W | 68–62 | Regular | John Glaser Arena |
| 15 | 2010-01-10 | 2009–10 | Xavier | George Washington | A10 | Away | W | 76–69 | Regular | Charles E. Smith Center |
| 16 | 2010-01-13 | 2009–10 | Xavier | Charlotte | A10 | Home | W | 86–74 | Regular | Cintas Center |
| 17 | 2010-01-16 | 2009–10 | Xavier | Dayton | A10 | Home | W | 78–74 | Regular | Cintas Center |
| 18 | 2010-01-20 | 2009–10 | Xavier | #16 Temple | A10 | Away | L | 72–77 | Regular | Liacouras Center |
| 19 | 2010-01-23 | 2009–10 | Xavier | Rhode Island | A10 | Home | W | 72–61 | Regular | Cintas Center |
| 20 | 2010-01-28 | 2009–10 | Xavier | Duquesne | A10 | Home | W | 86–50 | Regular | Cintas Center |
| 21 | 2010-01-31 | 2009–10 | Xavier | Fordham | A10 | Home | W | 108–60 | Regular | Cintas Center |
| 22 | 2010-02-03 | 2009–10 | Xavier | Massachusetts | A10 | Away | W | 87–79 | Regular | Mullins Center |
| 23 | 2010-02-06 | 2009–10 | Xavier | Dayton | A10 | Away | L | 65–90 | Regular | University of Dayton Arena |
| 24 | 2010-02-13 | 2009–10 | Xavier | Florida | SEC | Away | W | 76–64 | Regular | Stephen C. O'Connell Center |
| 25 | 2010-02-17 | 2009–10 | Xavier | Saint Joseph's | A10 | Home | W | 88–52 | Regular | Cintas Center |
| 26 | 2010-02-20 | 2009–10 | Xavier | Charlotte | A10 | Away | W | 81–67 | Regular | Dale F. Halton Arena |
| 27 | 2010-02-24 | 2009–10 | Xavier | Saint Louis | A10 | Away | W | 73–71 | Regular | Chaifetz Arena |
| 28 | 2010-02-28 | 2009–10 | Xavier | #23 Richmond | A10 | Home | W | 78–76 2OT | Regular | Cintas Center |
| 29 | 2010-03-03 | 2009–10 | #25 Xavier | Fordham | A10 | Away | W | 82–56 | Regular | Rose Hill Gymnasium |
| 30 | 2010-03-06 | 2009–10 | #25 Xavier | St. Bonaventure | A10 | Home | W | 93–72 | Regular | Cintas Center |
| 31 | 2010-11-12 | 2010–11 | Xavier | Western Michigan | MAC | Home | W | 68–65 | Regular | Cintas Center |
| 32 | 2010-11-16 | 2010–11 | Xavier | Purdue Fort Wayne | Summit | Home | W | 76–66 OT | Regular | Cintas Center |
| 33 | 2010-11-19 | 2010–11 | Xavier | Iowa | B10 | Neutral | W | 86–73 | Regular | UVI Sports and Fitness Center |
| 34 | 2010-11-21 | 2010–11 | Xavier | Seton Hall | Big East | Neutral | W | 57–52 | Regular | UVI Sports and Fitness Center |
| 35 | 2010-11-22 | 2010–11 | Xavier | Old Dominion | Colonial | Neutral | L | 58–67 | Regular | UVI Sports and Fitness Center |
| 36 | 2010-11-27 | 2010–11 | Xavier | Wofford | SoCon | Home | W | 94–90 3OT | Regular | Cintas Center |
| 37 | 2010-12-01 | 2010–11 | Xavier | Miami (OH) | MAC | Away | L | 64–75 | Regular | Millett Hall |
| 38 | 2010-12-09 | 2010–11 | Xavier | Butler | Horizon | Home | W | 51–49 | Regular | Cintas Center |
| 39 | 2010-12-18 | 2010–11 | Xavier | Wake Forest | ACC | Home | W | 83–75 | Regular | Cintas Center |
| 40 | 2010-12-22 | 2010–11 | Xavier | Gonzaga | WCC | Away | L | 54–64 | Regular | McCarthey Athletic Center |
| 41 | 2010-12-28 | 2010–11 | Xavier | Albany (NY) | Am. East | Home | W | 88–64 | Regular | Cintas Center |
| 42 | 2010-12-31 | 2010–11 | Xavier | Florida | SEC | Home | L | 67–71 | Regular | Cintas Center |
| 43 | 2011-01-06 | 2010–11 | Xavier | #24 Cincinnati | Big East | Away | L | 46–66 | Regular | Fifth Third Arena |
| 44 | 2011-01-09 | 2010–11 | Xavier | Rhode Island | A10 | Away | W | 72–45 | Regular | Ryan Center |
| 45 | 2011-01-12 | 2010–11 | Xavier | Massachusetts | A10 | Home | W | 79–50 | Regular | Cintas Center |
| 46 | 2011-01-15 | 2010–11 | Xavier | Dayton | A10 | Home | W | 81–76 | Regular | Cintas Center |
| 47 | 2011-01-19 | 2010–11 | Xavier | St. Bonaventure | A10 | Away | W | 79–65 | Regular | Reilly Center |
| 48 | 2011-01-22 | 2010–11 | Xavier | Temple | A10 | Home | W | 88–77 | Regular | Cintas Center |
| 49 | 2011-01-26 | 2010–11 | Xavier | George Washington | A10 | Home | W | 81–74 | Regular | Cintas Center |
| 50 | 2011-01-29 | 2010–11 | Xavier | Richmond | A10 | Away | W | 85–62 | Regular | Robins Center |
| 51 | 2011-02-02 | 2010–11 | Xavier | Charlotte | A10 | Away | L | 62–66 | Regular | Dale F. Halton Arena |
| 52 | 2011-02-05 | 2010–11 | Xavier | Saint Louis | A10 | Home | W | 76–68 | Regular | Cintas Center |
| 53 | 2011-02-08 | 2010–11 | Xavier | Georgia | SEC | Away | W | 65–57 | Regular | Stegeman Coliseum |
| 54 | 2011-02-13 | 2010–11 | Xavier | Duquesne | A10 | Neutral | W | 71–63 | Regular | PPG Paints Arena |
| 55 | 2011-02-16 | 2010–11 | #24 Xavier | Saint Joseph's | A10 | Away | W | 74–54 | Regular | Hagan Arena |
| 56 | 2011-02-19 | 2010–11 | #24 Xavier | Fordham | A10 | Home | W | 79–72 | Regular | Cintas Center |
| 57 | 2011-02-22 | 2010–11 | #25 Xavier | La Salle | A10 | Home | W | 100–62 | Regular | Cintas Center |
| 58 | 2011-02-27 | 2010–11 | #25 Xavier | Dayton | A10 | Away | W | 66–62 | Regular | University of Dayton Arena |
| 59 | 2011-03-02 | 2010–11 | #23 Xavier | Charlotte | A10 | Home | W | 68–48 | Regular | Cintas Center |
| 60 | 2011-03-05 | 2010–11 | #23 Xavier | Saint Louis | A10 | Away | W | 66–55 | Regular | Chaifetz Arena |
| 61 | 2011-11-11 | 2011–12 | #14 Xavier | Morgan State | MEAC | Home | W | 74–63 | Regular | Cintas Center |
| 62 | 2011-11-15 | 2011–12 | #13 Xavier | Purdue Fort Wayne | Summit | Home | W | 86–63 | Regular | Cintas Center |
| 63 | 2011-11-18 | 2011–12 | #13 Xavier | Miami (OH) | MAC | Home | W | 66–60 | Regular | Cintas Center |
| 64 | 2011-11-25 | 2011–12 | #12 Xavier | Georgia | SEC | Home | W | 70–56 | Regular | Cintas Center |
| 65 | 2011-11-28 | 2011–12 | #11 Xavier | #20 Vanderbilt | SEC | Away | W | 82–70 OT | Regular | Memorial Gymnasium |
| 66 | 2011-12-03 | 2011–12 | #11 Xavier | Purdue | B10 | Home | W | 66–63 | Regular | Cintas Center |
| 67 | 2011-12-07 | 2011–12 | #8 Xavier | Butler | Horizon | Away | W | 73–61 | Regular | Hinkle Fieldhouse |
| 68 | 2011-12-10 | 2011–12 | #8 Xavier | Cincinnati | Big East | Home | W | 76–53 | Regular | Cintas Center |
| 69 | 2011-12-18 | 2011–12 | #8 Xavier | Oral Roberts | Summit | Home | L | 42–64 | Regular | Cintas Center |
| 70 | 2011-12-22 | 2011–12 | #14 Xavier | Long Beach State | Big West | Neutral | L | 58–68 | Regular | Stan Sheriff Center |
| 71 | 2011-12-24 | 2011–12 | #14 Xavier | Hawaii | WAC | Neutral | L | 82–84 OT | Regular | Stan Sheriff Center |
| 72 | 2011-12-25 | 2011–12 | #14 Xavier | Southern Illinois | Missouri Valley | Neutral | W | 87–77 | Regular | Stan Sheriff Center |
| 73 | 2011-12-31 | 2011–12 | #14 Xavier | Gonzaga | WCC | Home | L | 65–72 | Regular | Cintas Center |
| 74 | 2012-01-04 | 2011–12 | #14 Xavier | La Salle | A10 | Away | L | 70–80 | Regular | John Glaser Arena |
| 75 | 2012-01-07 | 2011–12 | #14 Xavier | Fordham | A10 | Away | W | 67–59 | Regular | Rose Hill Gymnasium |
| 76 | 2012-01-11 | 2011–12 | #14 Xavier | Duquesne | A10 | Home | W | 78–50 | Regular | Cintas Center |
| 77 | 2012-01-14 | 2011–12 | #14 Xavier | St. Bonaventure | A10 | Home | W | 77–64 | Regular | Cintas Center |
| 78 | 2012-01-18 | 2011–12 | #14 Xavier | Saint Joseph's | A10 | Home | W | 68–55 | Regular | Cintas Center |
| 79 | 2012-01-21 | 2011–12 | #14 Xavier | Dayton | A10 | Away | L | 72–87 | Regular | University of Dayton Arena |
| 80 | 2012-01-25 | 2011–12 | #14 Xavier | Saint Louis | A10 | Home | L | 68–73 | Regular | Cintas Center |
| 81 | 2012-01-28 | 2011–12 | #14 Xavier | Charlotte | A10 | Away | W | 74–70 | Regular | Dale F. Halton Arena |
| 82 | 2012-02-01 | 2011–12 | #14 Xavier | George Washington | A10 | Away | W | 59–58 | Regular | Charles E. Smith Center |
| 83 | 2012-02-04 | 2011–12 | #14 Xavier | Memphis | CUSA | Away | L | 68–72 | Regular | FedExForum |
| 84 | 2012-02-08 | 2011–12 | #14 Xavier | Rhode Island | A10 | Home | W | 84–66 | Regular | Cintas Center |
| 85 | 2012-02-11 | 2011–12 | #14 Xavier | Temple | A10 | Away | L | 72–85 | Regular | Liacouras Center |
| 86 | 2012-02-18 | 2011–12 | #14 Xavier | Dayton | A10 | Home | W | 86–83 OT | Regular | Cintas Center |
| 87 | 2012-02-21 | 2011–12 | #14 Xavier | Massachusetts | A10 | Away | L | 73–80 | Regular | Mullins Center |
| 88 | 2012-02-25 | 2011–12 | #14 Xavier | Richmond | A10 | Home | W | 65–57 | Regular | Cintas Center |
| 89 | 2012-02-28 | 2011–12 | #14 Xavier | Saint Louis | A10 | Away | L | 59–70 | Regular | Chaifetz Arena |
| 90 | 2012-03-03 | 2011–12 | #14 Xavier | Charlotte | A10 | Home | W | 72–63 | Regular | Cintas Center |
| 91 | 2012-11-09 | 2012–13 | Xavier | FDU | NEC | Home | W | 117–75 | Regular | Cintas Center |
| 92 | 2012-11-13 | 2012–13 | Xavier | Butler | A10 | Home | W | 62–47 | Regular | Cintas Center |
| 93 | 2012-11-17 | 2012–13 | Xavier | Robert Morris | NEC | Home | W | 61–59 | Regular | Cintas Center |
| 94 | 2012-11-22 | 2012–13 | Xavier | Pacific | Big West | Neutral | L | 67–70 | Regular | Anaheim Convention Center |
| 95 | 2012-11-23 | 2012–13 | Xavier | Drexel | Colonial | Neutral | W | 69–65 | Regular | Anaheim Convention Center |
| 96 | 2012-11-25 | 2012–13 | Xavier | Drake | Missouri Valley | Neutral | W | 74–70 | Regular | Anaheim Convention Center |
| 97 | 2012-12-01 | 2012–13 | Xavier | Purdue | B10 | Away | W | 63–57 | Regular | Mackey Arena |
| 98 | 2012-12-06 | 2012–13 | Xavier | Vanderbilt | SEC | Home | L | 64–66 OT | Regular | Cintas Center |
| 99 | 2012-12-09 | 2012–13 | Xavier | Kent State | MAC | Home | W | 62–55 | Regular | Cintas Center |
| 100 | 2012-12-19 | 2012–13 | Xavier | #11 Cincinnati | Big East | Neutral | L | 45–60 | Regular | Heritage Bank Center |
| 101 | 2012-12-22 | 2012–13 | Xavier | Wofford | SoCon | Home | L | 55–56 | Regular | Cintas Center |
| 102 | 2012-12-29 | 2012–13 | Xavier | Tennessee | SEC | Away | L | 47–51 | Regular | Thompson-Boling Arena |
| 103 | 2013-01-02 | 2012–13 | Xavier | Wake Forest | ACC | Away | L | 59–66 | Regular | Lawrence Joel Veterans Memorial Coliseum |
| 104 | 2013-01-10 | 2012–13 | Xavier | Temple | A10 | Home | W | 57–52 | Regular | Cintas Center |
| 105 | 2013-01-12 | 2012–13 | Xavier | George Washington | A10 | Home | W | 71–56 | Regular | Cintas Center |
| 106 | 2013-01-16 | 2012–13 | Xavier | St. Bonaventure | A10 | Away | W | 66–64 | Regular | Reilly Center |
| 107 | 2013-01-19 | 2012–13 | Xavier | La Salle | A10 | Home | W | 70–63 | Regular | Cintas Center |
| 108 | 2013-01-23 | 2012–13 | Xavier | Charlotte | A10 | Away | L | 57–63 | Regular | Dale F. Halton Arena |
| 109 | 2013-01-26 | 2012–13 | Xavier | Saint Joseph's | A10 | Away | L | 49–59 | Regular | Hagan Arena |
| 110 | 2013-01-30 | 2012–13 | Xavier | Dayton | A10 | Home | W | 66–61 | Regular | Cintas Center |
| 111 | 2013-02-02 | 2012–13 | Xavier | Richmond | A10 | Away | L | 71–73 | Regular | Robins Center |
| 112 | 2013-02-09 | 2012–13 | Xavier | Duquesne | A10 | Away | W | 73–65 | Regular | UPMC Cooper Fieldhouse |
| 113 | 2013-02-13 | 2012–13 | Xavier | Fordham | A10 | Home | W | 79–66 | Regular | Cintas Center |
| 114 | 2013-02-16 | 2012–13 | Xavier | Dayton | A10 | Away | L | 59–70 | Regular | University of Dayton Arena |
| 115 | 2013-02-20 | 2012–13 | Xavier | Rhode Island | A10 | Away | W | 55–42 | Regular | Ryan Center |
| 116 | 2013-02-23 | 2012–13 | Xavier | #24 Virginia Commonwealth | A10 | Home | L | 71–75 | Regular | Cintas Center |
| 117 | 2013-02-26 | 2012–13 | Xavier | #19 Memphis | CUSA | Home | W | 64–62 | Regular | Cintas Center |
| 118 | 2013-03-02 | 2012–13 | Xavier | Massachusetts | A10 | Home | L | 72–77 | Regular | Cintas Center |
| 119 | 2013-03-06 | 2012–13 | Xavier | #16 Saint Louis | A10 | Home | W | 77–66 OT | Regular | Cintas Center |
| 120 | 2013-03-09 | 2012–13 | Xavier | Butler | A10 | Away | L | 62–67 | Regular | Hinkle Fieldhouse |
| 121 | 2013-11-08 | 2013–14 | Xavier | Gardner-Webb | Big South | Home | W | 83–59 | Regular | Cintas Center |
| 122 | 2013-11-12 | 2013–14 | Xavier | Tennessee | SEC | Home | W | 67–63 | Regular | Cintas Center |
| 123 | 2013-11-15 | 2013–14 | Xavier | Morehead State | OVC | Home | W | 79–56 | Regular | Cintas Center |
| 124 | 2013-11-20 | 2013–14 | Xavier | Miami (OH) | MAC | Home | W | 77–51 | Regular | Cintas Center |
| 125 | 2013-11-25 | 2013–14 | Xavier | Abilene Christian | Southland | Home | W | 93–65 | Regular | Cintas Center |
| 126 | 2013-11-28 | 2013–14 | Xavier | #23 Iowa | B10 | Neutral | L | 74–77 OT | Regular | Imperial Arena |
| 127 | 2013-11-29 | 2013–14 | Xavier | Tennessee | SEC | Neutral | L | 49–64 | Regular | Imperial Arena |
| 128 | 2013-11-30 | 2013–14 | Xavier | Southern California | Pacific 12 | Neutral | L | 78–84 | Regular | Imperial Arena |
| 129 | 2013-12-07 | 2013–14 | Xavier | Bowling Green | MAC | Home | W | 85–73 OT | Regular | Cintas Center |
| 130 | 2013-12-10 | 2013–14 | Xavier | Evansville | Missouri Valley | Home | W | 63–60 | Regular | Cintas Center |
| 131 | 2013-12-14 | 2013–14 | Xavier | Cincinnati | AAC | Neutral | W | 64–47 | Regular | Cintas Center |
| 132 | 2013-12-21 | 2013–14 | Xavier | Alabama | SEC | Away | W | 77–74 | Regular | Coleman Coliseum |
| 133 | 2013-12-28 | 2013–14 | Xavier | Wake Forest | ACC | Home | W | 68–53 | Regular | Cintas Center |
| 134 | 2013-12-31 | 2013–14 | Xavier | St. John's (NY) | Big East | Home | W | 70–60 | Regular | Cintas Center |
| 135 | 2014-01-04 | 2013–14 | Xavier | Butler | Big East | Home | W | 79–68 | Regular | Cintas Center |
| 136 | 2014-01-09 | 2013–14 | Xavier | Marquette | Big East | Home | W | 86–79 | Regular | Cintas Center |
| 137 | 2014-01-12 | 2013–14 | Xavier | Creighton | Big East | Away | L | 89–95 | Regular | CHI Health Center Omaha |
| 138 | 2014-01-15 | 2013–14 | Xavier | Georgetown | Big East | Home | W | 80–67 | Regular | Cintas Center |
| 139 | 2014-01-20 | 2013–14 | Xavier | DePaul | Big East | Away | W | 84–74 | Regular | Allstate Arena |
| 140 | 2014-01-25 | 2013–14 | Xavier | Providence | Big East | Away | L | 72–81 | Regular | Amica Mutual Pavilion |
| 141 | 2014-02-01 | 2013–14 | Xavier | Seton Hall | Big East | Home | L | 60–68 | Regular | Cintas Center |
| 142 | 2014-02-03 | 2013–14 | Xavier | #6 Villanova | Big East | Away | L | 58–81 | Regular | Xfinity Mobile Arena |
| 143 | 2014-02-08 | 2013–14 | Xavier | Providence | Big East | Home | W | 59–53 | Regular | Cintas Center |
| 144 | 2014-02-11 | 2013–14 | Xavier | Butler | Big East | Away | W | 64–50 | Regular | Hinkle Fieldhouse |
| 145 | 2014-02-15 | 2013–14 | Xavier | Marquette | Big East | Away | L | 72–81 | Regular | Bradley Center |
| 146 | 2014-02-19 | 2013–14 | Xavier | DePaul | Big East | Home | W | 83–64 | Regular | Cintas Center |
| 147 | 2014-02-22 | 2013–14 | Xavier | Georgetown | Big East | Away | L | 52–74 | Regular | Capital One Arena |
| 148 | 2014-02-25 | 2013–14 | Xavier | St. John's (NY) | Big East | Away | W | 65–53 | Regular | Madison Square Garden |
| 149 | 2014-03-01 | 2013–14 | Xavier | #9 Creighton | Big East | Home | W | 75–69 | Regular | Cintas Center |
| 150 | 2014-03-03 | 2013–14 | Xavier | Seton Hall | Big East | Away | L | 62–71 | Regular | Prudential Center |
| 151 | 2014-03-06 | 2013–14 | Xavier | #6 Villanova | Big East | Home | L | 70–77 | Regular | Cintas Center |
| 152 | 2014-11-14 | 2014–15 | Xavier | Northern Arizona | Big Sky | Home | W | 93–60 | Regular | Cintas Center |
| 153 | 2014-11-18 | 2014–15 | Xavier | Long Beach State | Big West | Home | W | 97–74 | Regular | Cintas Center |
| 154 | 2014-11-21 | 2014–15 | Xavier | Stephen F. Austin | Southland | Home | W | 81–63 | Regular | Cintas Center |
| 155 | 2014-11-24 | 2014–15 | Xavier | Murray State | OVC | Home | W | 89–62 | Regular | Cintas Center |
| 156 | 2014-11-27 | 2014–15 | Xavier | San Diego | WCC | Neutral | W | 82–71 | Regular | Titan Gym |
| 157 | 2014-11-28 | 2014–15 | Xavier | UTEP | CUSA | Neutral | L | 73–77 | Regular | Honda Center |
| 158 | 2014-11-30 | 2014–15 | Xavier | Long Beach State | Big West | Neutral | L | 70–73 | Regular | Honda Center |
| 159 | 2014-12-06 | 2014–15 | Xavier | Alabama | SEC | Home | W | 97–84 | Regular | Cintas Center |
| 160 | 2014-12-09 | 2014–15 | Xavier | IU Indy | Summit | Home | W | 66–43 | Regular | Cintas Center |
| 161 | 2014-12-13 | 2014–15 | Xavier | Missouri | SEC | Away | W | 74–58 | Regular | Mizzou Arena |
| 162 | 2014-12-20 | 2014–15 | Xavier | Auburn | SEC | Away | L | 88–89 2OT | Regular | Neville Arena |
| 163 | 2014-12-28 | 2014–15 | Xavier | Florida Gulf Coast | ASUN | Home | W | 71–57 | Regular | Cintas Center |
| 164 | 2014-12-31 | 2014–15 | Xavier | #25 Georgetown | Big East | Home | W | 70–53 | Regular | Cintas Center |
| 165 | 2015-01-03 | 2014–15 | Xavier | DePaul | Big East | Away | L | 68–71 | Regular | Allstate Arena |
| 166 | 2015-01-07 | 2014–15 | Xavier | #19 Seton Hall | Big East | Home | W | 69–58 | Regular | Cintas Center |
| 167 | 2015-01-10 | 2014–15 | Xavier | Butler | Big East | Away | L | 76–88 | Regular | Hinkle Fieldhouse |
| 168 | 2015-01-14 | 2014–15 | Xavier | #5 Villanova | Big East | Away | L | 75–88 | Regular | Finneran Pavilion |
| 169 | 2015-01-17 | 2014–15 | Xavier | Marquette | Big East | Home | W | 62–58 | Regular | Cintas Center |
| 170 | 2015-01-22 | 2014–15 | Xavier | Providence | Big East | Away | L | 66–69 OT | Regular | Amica Mutual Pavilion |
| 171 | 2015-01-24 | 2014–15 | Xavier | DePaul | Big East | Home | W | 89–76 | Regular | Cintas Center |
| 172 | 2015-01-27 | 2014–15 | Xavier | #21 Georgetown | Big East | Away | W | 66–53 | Regular | Capital One Arena |
| 173 | 2015-01-31 | 2014–15 | Xavier | Seton Hall | Big East | Away | L | 82–90 | Regular | Prudential Center |
| 174 | 2015-02-04 | 2014–15 | Xavier | Creighton | Big East | Home | L | 72–79 OT | Regular | Cintas Center |
| 175 | 2015-02-07 | 2014–15 | Xavier | Providence | Big East | Home | W | 78–69 | Regular | Cintas Center |
| 176 | 2015-02-10 | 2014–15 | Xavier | Marquette | Big East | Away | W | 64–44 | Regular | Bradley Center |
| 177 | 2015-02-14 | 2014–15 | Xavier | St. John's (NY) | Big East | Home | L | 70–78 | Regular | Cintas Center |
| 178 | 2015-02-18 | 2014–15 | Xavier | Cincinnati | AAC | Away | W | 59–57 | Regular | Fifth Third Arena |
| 179 | 2015-02-21 | 2014–15 | Xavier | #19 Butler | Big East | Home | W | 73–56 | Regular | Cintas Center |
| 180 | 2015-02-23 | 2014–15 | Xavier | St. John's (NY) | Big East | Away | L | 57–58 | Regular | Madison Square Garden |
| 181 | 2015-02-28 | 2014–15 | Xavier | #6 Villanova | Big East | Home | L | 66–78 | Regular | Cintas Center |
| 182 | 2015-03-07 | 2014–15 | Xavier | Creighton | Big East | Away | W | 74–73 | Regular | CHI Health Center Omaha |
| 183 | 2015-11-13 | 2015–16 | Xavier | Miami (OH) | MAC | Home | W | 81–72 | Regular | Cintas Center |
| 184 | 2015-11-17 | 2015–16 | Xavier | Missouri | SEC | Home | W | 78–66 | Regular | Cintas Center |
| 185 | 2015-11-20 | 2015–16 | Xavier | #24 Michigan | B10 | Away | W | 86–70 | Regular | Crisler Center |
| 186 | 2015-11-23 | 2015–16 | #23 Xavier | Northern Kentucky | Horizon | Home | W | 78–66 | Regular | Cintas Center |
| 187 | 2015-11-26 | 2015–16 | #23 Xavier | Alabama | SEC | Neutral | W | 64–45 | Regular | State Farm Field House |
| 188 | 2015-11-27 | 2015–16 | #23 Xavier | Southern California | Pacific 12 | Neutral | W | 87–77 | Regular | State Farm Field House |
| 189 | 2015-11-29 | 2015–16 | #23 Xavier | Dayton | A10 | Neutral | W | 90–61 | Regular | State Farm Field House |
| 190 | 2015-12-05 | 2015–16 | #12 Xavier | Western Kentucky | CUSA | Home | W | 95–64 | Regular | Cintas Center |
| 191 | 2015-12-08 | 2015–16 | #12 Xavier | Wright State | Horizon | Home | W | 90–55 | Regular | Cintas Center |
| 192 | 2015-12-12 | 2015–16 | #12 Xavier | #23 Cincinnati | AAC | Home | W | 65–55 | Regular | Cintas Center |
| 193 | 2015-12-19 | 2015–16 | #10 Xavier | Auburn | SEC | Home | W | 85–61 | Regular | Cintas Center |
| 194 | 2015-12-22 | 2015–16 | #6 Xavier | Wake Forest | ACC | Away | W | 78–70 | Regular | Lawrence Joel Veterans Memorial Coliseum |
| 195 | 2015-12-31 | 2015–16 | #6 Xavier | #16 Villanova | Big East | Away | L | 64–95 | Regular | Finneran Pavilion |
| 196 | 2016-01-02 | 2015–16 | #6 Xavier | #9 Butler | Big East | Home | W | 88–69 | Regular | Cintas Center |
| 197 | 2016-01-06 | 2015–16 | #10 Xavier | St. John's (NY) | Big East | Away | W | 74–66 | Regular | Carnesecca Arena |
| 198 | 2016-01-12 | 2015–16 | #7 Xavier | DePaul | Big East | Home | W | 84–64 | Regular | Cintas Center |
| 199 | 2016-01-16 | 2015–16 | #7 Xavier | Marquette | Big East | Away | W | 74–66 | Regular | Bradley Center |
| 200 | 2016-01-19 | 2015–16 | #5 Xavier | Georgetown | Big East | Home | L | 72–81 | Regular | Cintas Center |
| 201 | 2016-01-23 | 2015–16 | #5 Xavier | Seton Hall | Big East | Home | W | 84–76 | Regular | Cintas Center |
| 202 | 2016-01-26 | 2015–16 | #7 Xavier | #10 Providence | Big East | Away | W | 75–68 | Regular | Amica Mutual Pavilion |
| 203 | 2016-01-30 | 2015–16 | #7 Xavier | DePaul | Big East | Away | W | 86–65 | Regular | Allstate Arena |
| 204 | 2016-02-03 | 2015–16 | #6 Xavier | St. John's (NY) | Big East | Home | W | 90–83 | Regular | Cintas Center |
| 205 | 2016-02-06 | 2015–16 | #6 Xavier | Marquette | Big East | Home | W | 90–82 | Regular | Cintas Center |
| 206 | 2016-02-09 | 2015–16 | #5 Xavier | Creighton | Big East | Away | L | 56–70 | Regular | CHI Health Center Omaha |
| 207 | 2016-02-13 | 2015–16 | #5 Xavier | Butler | Big East | Away | W | 74–57 | Regular | Hinkle Fieldhouse |
| 208 | 2016-02-17 | 2015–16 | #8 Xavier | #23 Providence | Big East | Home | W | 85–74 | Regular | Cintas Center |
| 209 | 2016-02-20 | 2015–16 | #8 Xavier | Georgetown | Big East | Away | W | 88–70 | Regular | Capital One Arena |
| 210 | 2016-02-24 | 2015–16 | #5 Xavier | #1 Villanova | Big East | Home | W | 90–83 | Regular | Cintas Center |
| 211 | 2016-02-28 | 2015–16 | #5 Xavier | Seton Hall | Big East | Away | L | 81–90 | Regular | Prudential Center |
| 212 | 2016-03-05 | 2015–16 | #5 Xavier | Creighton | Big East | Home | W | 98–93 | Regular | Cintas Center |
| 213 | 2016-11-11 | 2016–17 | #7 Xavier | Lehigh | Patriot | Home | W | 84–81 | Regular | Cintas Center |
| 214 | 2016-11-14 | 2016–17 | #11 Xavier | Buffalo | MAC | Home | W | 86–53 | Regular | Cintas Center |
| 215 | 2016-11-17 | 2016–17 | #11 Xavier | Missouri | SEC | Neutral | W | 83–82 OT | Regular | State Farm Field House |
| 216 | 2016-11-18 | 2016–17 | #11 Xavier | Clemson | ACC | Neutral | W | 83–77 | Regular | State Farm Field House |
| 217 | 2016-11-20 | 2016–17 | #11 Xavier | Northern Iowa | Missouri Valley | Neutral | W | 67–59 | Regular | State Farm Field House |
| 218 | 2016-11-26 | 2016–17 | #9 Xavier | Northern Iowa | Missouri Valley | Home | W | 64–42 | Regular | Cintas Center |
| 219 | 2016-11-29 | 2016–17 | #7 Xavier | North Dakota State | Summit | Home | W | 85–55 | Regular | Cintas Center |
| 220 | 2016-12-03 | 2016–17 | #7 Xavier | #9 Baylor | B12 | Away | L | 61–76 | Regular | Ferrell Center |
| 221 | 2016-12-07 | 2016–17 | #13 Xavier | Colorado | Pacific 12 | Away | L | 66–68 | Regular | CU Events Center |
| 222 | 2016-12-10 | 2016–17 | #13 Xavier | Utah | Pacific 12 | Home | W | 77–69 | Regular | Cintas Center |
| 223 | 2016-12-17 | 2016–17 | #17 Xavier | Wake Forest | ACC | Home | W | 69–65 | Regular | Cintas Center |
| 224 | 2016-12-20 | 2016–17 | #17 Xavier | Eastern Washington | Big Sky | Home | W | 85–56 | Regular | Cintas Center |
| 225 | 2016-12-28 | 2016–17 | #17 Xavier | Providence | Big East | Home | W | 82–56 | Regular | Cintas Center |
| 226 | 2016-12-31 | 2016–17 | #17 Xavier | Georgetown | Big East | Away | W | 81–76 | Regular | Capital One Arena |
| 227 | 2017-01-07 | 2016–17 | #16 Xavier | St. John's (NY) | Big East | Home | W | 97–82 | Regular | Cintas Center |
| 228 | 2017-01-10 | 2016–17 | #15 Xavier | #3 Villanova | Big East | Away | L | 54–79 | Regular | Finneran Pavilion |
| 229 | 2017-01-14 | 2016–17 | #15 Xavier | #12 Butler | Big East | Away | L | 78–83 | Regular | Hinkle Fieldhouse |
| 230 | 2017-01-16 | 2016–17 | #22 Xavier | #7 Creighton | Big East | Home | L | 67–72 | Regular | Cintas Center |
| 231 | 2017-01-22 | 2016–17 | #22 Xavier | Georgetown | Big East | Home | W | 86–75 | Regular | Cintas Center |
| 232 | 2017-01-26 | 2016–17 | #24 Xavier | #19 Cincinnati | AAC | Away | L | 78–86 | Regular | Fifth Third Arena |
| 233 | 2017-01-29 | 2016–17 | #24 Xavier | St. John's (NY) | Big East | Away | W | 82–77 | Regular | Madison Square Garden |
| 234 | 2017-02-01 | 2016–17 | #24 Xavier | Seton Hall | Big East | Home | W | 72–70 | Regular | Cintas Center |
| 235 | 2017-02-04 | 2016–17 | #24 Xavier | #22 Creighton | Big East | Away | W | 82–80 | Regular | CHI Health Center Omaha |
| 236 | 2017-02-08 | 2016–17 | #24 Xavier | DePaul | Big East | Home | W | 72–61 | Regular | Cintas Center |
| 237 | 2017-02-11 | 2016–17 | #24 Xavier | #2 Villanova | Big East | Home | L | 57–73 | Regular | Cintas Center |
| 238 | 2017-02-15 | 2016–17 | #24 Xavier | Providence | Big East | Away | L | 63–75 | Regular | Amica Mutual Pavilion |
| 239 | 2017-02-18 | 2016–17 | #24 Xavier | Marquette | Big East | Away | L | 61–83 | Regular | Bradley Center |
| 240 | 2017-02-22 | 2016–17 | #24 Xavier | Seton Hall | Big East | Away | L | 64–71 | Regular | Prudential Center |
| 241 | 2017-02-26 | 2016–17 | #24 Xavier | #22 Butler | Big East | Home | L | 79–88 | Regular | Cintas Center |
| 242 | 2017-03-01 | 2016–17 | #24 Xavier | Marquette | Big East | Home | L | 84–95 | Regular | Cintas Center |
| 243 | 2017-03-04 | 2016–17 | #24 Xavier | DePaul | Big East | Away | W | 79–65 | Regular | Allstate Arena |
| 244 | 2017-11-10 | 2017–18 | #17 Xavier | Morehead State | OVC | Home | W | 101–49 | Regular | Cintas Center |
| 245 | 2017-11-13 | 2017–18 | #15 Xavier | Rider | MAAC | Home | W | 101–75 | Regular | Cintas Center |
| 246 | 2017-11-16 | 2017–18 | #15 Xavier | Wisconsin | B10 | Away | W | 80–70 | Regular | Kohl Center |
| 247 | 2017-11-20 | 2017–18 | #15 Xavier | Hampton | MEAC | Home | W | 96–60 | Regular | Cintas Center |
| 248 | 2017-11-23 | 2017–18 | #15 Xavier | George Washington | A10 | Neutral | W | 83–64 | Regular | Orleans Arena |
| 249 | 2017-11-24 | 2017–18 | #15 Xavier | Arizona State | Pacific 12 | Neutral | L | 86–102 | Regular | Orleans Arena |
| 250 | 2017-11-28 | 2017–18 | #21 Xavier | #16 Baylor | B12 | Home | W | 76–63 | Regular | Cintas Center |
| 251 | 2017-12-02 | 2017–18 | #21 Xavier | #11 Cincinnati | AAC | Home | W | 89–76 | Regular | Cintas Center |
| 252 | 2017-12-06 | 2017–18 | #13 Xavier | Kent State | MAC | Home | W | 96–70 | Regular | Cintas Center |
| 253 | 2017-12-09 | 2017–18 | #13 Xavier | Colorado | Pacific 12 | Home | W | 96–69 | Regular | Cintas Center |
| 254 | 2017-12-16 | 2017–18 | #10 Xavier | East Tennessee State | SoCon | Home | W | 68–66 | Regular | Cintas Center |
| 255 | 2017-12-19 | 2017–18 | #9 Xavier | Marshall | CUSA | Home | W | 81–77 | Regular | Cintas Center |
| 256 | 2017-12-22 | 2017–18 | #9 Xavier | Northern Iowa | Missouri Valley | Away | W | 77–67 | Regular | McLeod Center |
| 257 | 2017-12-27 | 2017–18 | #6 Xavier | Marquette | Big East | Away | W | 91–87 | Regular | Bradley Center |
| 258 | 2017-12-30 | 2017–18 | #6 Xavier | DePaul | Big East | Home | W | 77–72 | Regular | Cintas Center |
| 259 | 2018-01-02 | 2017–18 | #5 Xavier | Butler | Big East | Home | W | 86–79 | Regular | Cintas Center |
| 260 | 2018-01-06 | 2017–18 | #5 Xavier | Providence | Big East | Away | L | 72–81 | Regular | Amica Mutual Pavilion |
| 261 | 2018-01-10 | 2017–18 | #10 Xavier | #1 Villanova | Big East | Away | L | 65–89 | Regular | Xfinity Mobile Arena |
| 262 | 2018-01-13 | 2017–18 | #10 Xavier | #25 Creighton | Big East | Home | W | 92–70 | Regular | Cintas Center |
| 263 | 2018-01-17 | 2017–18 | #11 Xavier | St. John's (NY) | Big East | Home | W | 88–82 | Regular | Cintas Center |
| 264 | 2018-01-20 | 2017–18 | #11 Xavier | #19 Seton Hall | Big East | Away | W | 73–64 | Regular | Prudential Center |
| 265 | 2018-01-24 | 2017–18 | #8 Xavier | Marquette | Big East | Home | W | 89–70 | Regular | Cintas Center |
| 266 | 2018-01-30 | 2017–18 | #6 Xavier | St. John's (NY) | Big East | Away | W | 73–68 | Regular | Carnesecca Arena |
| 267 | 2018-02-03 | 2017–18 | #6 Xavier | Georgetown | Big East | Home | W | 96–91 OT | Regular | Cintas Center |
| 268 | 2018-02-06 | 2017–18 | #5 Xavier | Butler | Big East | Away | W | 98–93 OT | Regular | Hinkle Fieldhouse |
| 269 | 2018-02-10 | 2017–18 | #5 Xavier | Creighton | Big East | Away | W | 72–71 | Regular | CHI Health Center Omaha |
| 270 | 2018-02-14 | 2017–18 | #4 Xavier | Seton Hall | Big East | Home | W | 102–90 | Regular | Cintas Center |
| 271 | 2018-02-17 | 2017–18 | #4 Xavier | #3 Villanova | Big East | Home | L | 79–95 | Regular | Cintas Center |
| 272 | 2018-02-21 | 2017–18 | #4 Xavier | Georgetown | Big East | Away | W | 89–77 | Regular | Capital One Arena |
| 273 | 2018-02-28 | 2017–18 | #3 Xavier | Providence | Big East | Home | W | 84–74 | Regular | Cintas Center |
| 274 | 2018-03-03 | 2017–18 | #3 Xavier | DePaul | Big East | Away | W | 65–62 | Regular | Wintrust Arena |
| 275 | 2018-11-08 | 2018–19 | Louisville | Nicholls State | Southland | Home | W | 85–72 | Regular | KFC Yum! Center |
| 276 | 2018-11-13 | 2018–19 | Louisville | Southern | SWAC | Home | W | 104–54 | Regular | KFC Yum! Center |
| 277 | 2018-11-16 | 2018–19 | Louisville | Vermont | Am. East | Home | W | 86–78 | Regular | KFC Yum! Center |
| 278 | 2018-11-21 | 2018–19 | Louisville | #5 Tennessee | SEC | Neutral | L | 81–92 | Regular | Barclays Center |
| 279 | 2018-11-23 | 2018–19 | Louisville | Marquette | Big East | Neutral | L | 74–77 OT | Regular | Barclays Center |
| 280 | 2018-11-27 | 2018–19 | Louisville | #9 Michigan State | B10 | Home | W | 82–78 OT | Regular | KFC Yum! Center |
| 281 | 2018-12-01 | 2018–19 | Louisville | Seton Hall | Big East | Away | W | 70–65 | Regular | Prudential Center |
| 282 | 2018-12-05 | 2018–19 | Louisville | Central Arkansas | Southland | Home | W | 86–41 | Regular | KFC Yum! Center |
| 283 | 2018-12-08 | 2018–19 | Louisville | Indiana | B10 | Away | L | 67–68 | Regular | Simon Skjodt Assembly Hall |
| 284 | 2018-12-12 | 2018–19 | Louisville | Lipscomb | ASUN | Home | W | 72–68 | Regular | KFC Yum! Center |
| 285 | 2018-12-15 | 2018–19 | Louisville | Kent State | MAC | Home | W | 83–70 | Regular | KFC Yum! Center |
| 286 | 2018-12-21 | 2018–19 | Louisville | Robert Morris | NEC | Home | W | 73–59 | Regular | KFC Yum! Center |
| 287 | 2018-12-29 | 2018–19 | Louisville | #16 Kentucky | SEC | Home | L | 58–71 | Regular | KFC Yum! Center |
| 288 | 2019-01-06 | 2018–19 | Louisville | Miami (FL) | ACC | Home | W | 90–73 | Regular | KFC Yum! Center |
| 289 | 2019-01-09 | 2018–19 | Louisville | Pittsburgh | ACC | Away | L | 86–89 OT | Regular | Petersen Events Center |
| 290 | 2019-01-12 | 2018–19 | Louisville | #12 North Carolina | ACC | Away | W | 83–62 | Regular | Dean Smith Center |
| 291 | 2019-01-16 | 2018–19 | Louisville | Boston College | ACC | Home | W | 80–70 | Regular | KFC Yum! Center |
| 292 | 2019-01-19 | 2018–19 | Louisville | Georgia Tech | ACC | Away | W | 79–51 | Regular | McCamish Pavilion |
| 293 | 2019-01-24 | 2018–19 | #23 Louisville | #21 NC State | ACC | Home | W | 84–77 | Regular | KFC Yum! Center |
| 294 | 2019-01-26 | 2018–19 | #23 Louisville | Pittsburgh | ACC | Home | W | 66–51 | Regular | KFC Yum! Center |
| 295 | 2019-01-30 | 2018–19 | #15 Louisville | Wake Forest | ACC | Away | W | 82–54 | Regular | Lawrence Joel Veterans Memorial Coliseum |
| 296 | 2019-02-02 | 2018–19 | #15 Louisville | #9 North Carolina | ACC | Home | L | 69–79 | Regular | KFC Yum! Center |
| 297 | 2019-02-04 | 2018–19 | #16 Louisville | #11 Virginia Tech | ACC | Away | W | 72–64 | Regular | Cassell Coliseum |
| 298 | 2019-02-09 | 2018–19 | #16 Louisville | #22 Florida State | ACC | Away | L | 75–80 OT | Regular | Donald L. Tucker Civic Center |
| 299 | 2019-02-12 | 2018–19 | #16 Louisville | #2 Duke | ACC | Home | L | 69–71 | Regular | KFC Yum! Center |
| 300 | 2019-02-16 | 2018–19 | #16 Louisville | Clemson | ACC | Home | W | 56–55 | Regular | KFC Yum! Center |
| 301 | 2019-02-20 | 2018–19 | #18 Louisville | Syracuse | ACC | Away | L | 49–69 | Regular | Carrier Dome |
| 302 | 2019-02-23 | 2018–19 | #18 Louisville | #3 Virginia | ACC | Home | L | 52–64 | Regular | KFC Yum! Center |
| 303 | 2019-02-27 | 2018–19 | #18 Louisville | Boston College | ACC | Away | L | 59–66 | Regular | Conte Forum |
| 304 | 2019-03-03 | 2018–19 | #18 Louisville | Notre Dame | ACC | Home | W | 75–61 | Regular | KFC Yum! Center |
| 305 | 2019-03-09 | 2018–19 | #18 Louisville | #2 Virginia | ACC | Away | L | 68–73 | Regular | John Paul Jones Arena |
| 306 | 2019-11-05 | 2019–20 | #5 Louisville | Miami (FL) | ACC | Away | W | 87–74 | Regular | Watsco Center |
| 307 | 2019-11-10 | 2019–20 | #5 Louisville | Youngstown State | Horizon | Home | W | 78–55 | Regular | KFC Yum! Center |
| 308 | 2019-11-13 | 2019–20 | #4 Louisville | Indiana State | Missouri Valley | Home | W | 91–62 | Regular | KFC Yum! Center |
| 309 | 2019-11-17 | 2019–20 | #4 Louisville | North Carolina Central | MEAC | Home | W | 87–58 | Regular | KFC Yum! Center |
| 310 | 2019-11-20 | 2019–20 | #2 Louisville | South Carolina Upstate | Big South | Home | W | 76–50 | Regular | KFC Yum! Center |
| 311 | 2019-11-24 | 2019–20 | #2 Louisville | Akron | MAC | Home | W | 82–76 | Regular | KFC Yum! Center |
| 312 | 2019-11-29 | 2019–20 | #2 Louisville | Western Kentucky | CUSA | Neutral | W | 71–54 | Regular | Bridgestone Arena |
| 313 | 2019-12-03 | 2019–20 | #1 Louisville | #4 Michigan | B10 | Home | W | 58–43 | Regular | KFC Yum! Center |
| 314 | 2019-12-06 | 2019–20 | #1 Louisville | Pittsburgh | ACC | Home | W | 64–46 | Regular | KFC Yum! Center |
| 315 | 2019-12-10 | 2019–20 | #1 Louisville | Texas Tech | B12 | Neutral | L | 57–70 | Regular | Madison Square Garden |
| 316 | 2019-12-14 | 2019–20 | #1 Louisville | Eastern Kentucky | OVC | Home | W | 99–67 | Regular | KFC Yum! Center |
| 317 | 2019-12-18 | 2019–20 | #3 Louisville | Miami (OH) | MAC | Home | W | 70–46 | Regular | KFC Yum! Center |
| 318 | 2019-12-28 | 2019–20 | #3 Louisville | #19 Kentucky | SEC | Away | L | 70–78 OT | Regular | Rupp Arena |
| 319 | 2020-01-04 | 2019–20 | #7 Louisville | #18 Florida State | ACC | Home | L | 65–78 | Regular | KFC Yum! Center |
| 320 | 2020-01-07 | 2019–20 | #13 Louisville | Miami (FL) | ACC | Home | W | 74–58 | Regular | KFC Yum! Center |
| 321 | 2020-01-11 | 2019–20 | #13 Louisville | Notre Dame | ACC | Away | W | 67–64 | Regular | Purcell Pavilion |
| 322 | 2020-01-14 | 2019–20 | #11 Louisville | Pittsburgh | ACC | Away | W | 73–68 OT | Regular | Petersen Events Center |
| 323 | 2020-01-18 | 2019–20 | #11 Louisville | #3 Duke | ACC | Away | W | 79–73 | Regular | Cameron Indoor Stadium |
| 324 | 2020-01-22 | 2019–20 | #6 Louisville | Georgia Tech | ACC | Home | W | 68–64 | Regular | KFC Yum! Center |
| 325 | 2020-01-25 | 2019–20 | #6 Louisville | Clemson | ACC | Home | W | 80–62 | Regular | KFC Yum! Center |
| 326 | 2020-01-29 | 2019–20 | #6 Louisville | Boston College | ACC | Away | W | 86–69 | Regular | Conte Forum |
| 327 | 2020-02-01 | 2019–20 | #6 Louisville | NC State | ACC | Away | W | 77–57 | Regular | Lenovo Center |
| 328 | 2020-02-05 | 2019–20 | #5 Louisville | Wake Forest | ACC | Home | W | 86–76 | Regular | KFC Yum! Center |
| 329 | 2020-02-08 | 2019–20 | #5 Louisville | Virginia | ACC | Home | W | 80–73 | Regular | KFC Yum! Center |
| 330 | 2020-02-12 | 2019–20 | #5 Louisville | Georgia Tech | ACC | Away | L | 58–64 | Regular | McCamish Pavilion |
| 331 | 2020-02-15 | 2019–20 | #5 Louisville | Clemson | ACC | Away | L | 62–77 | Regular | Littlejohn Coliseum |
| 332 | 2020-02-19 | 2019–20 | #11 Louisville | Syracuse | ACC | Home | W | 90–66 | Regular | KFC Yum! Center |
| 333 | 2020-02-22 | 2019–20 | #11 Louisville | North Carolina | ACC | Home | W | 72–55 | Regular | KFC Yum! Center |
| 334 | 2020-02-24 | 2019–20 | #11 Louisville | #6 Florida State | ACC | Away | L | 67–82 | Regular | Donald L. Tucker Civic Center |
| 335 | 2020-03-01 | 2019–20 | #11 Louisville | Virginia Tech | ACC | Home | W | 68–52 | Regular | KFC Yum! Center |
| 336 | 2020-03-07 | 2019–20 | #10 Louisville | #22 Virginia | ACC | Away | L | 54–57 | Regular | John Paul Jones Arena |
| 337 | 2020-11-25 | 2020–21 | Louisville | Evansville | Missouri Valley | Home | W | 79–44 | Regular | KFC Yum! Center |
| 338 | 2020-11-27 | 2020–21 | Louisville | Seton Hall | Big East | Home | W | 71–70 | Regular | KFC Yum! Center |
| 339 | 2020-11-29 | 2020–21 | Louisville | Prairie View | SWAC | Home | W | 86–64 | Regular | KFC Yum! Center |
| 340 | 2020-12-01 | 2020–21 | Louisville | Western Kentucky | CUSA | Home | W | 75–54 | Regular | KFC Yum! Center |
| 341 | 2020-12-19 | 2020–21 | #23 Louisville | #12 Wisconsin | B10 | Away | L | 48–85 | Regular | Kohl Center |
| 342 | 2020-12-22 | 2020–21 | #23 Louisville | Pittsburgh | ACC | Away | W | 64–54 | Regular | Petersen Events Center |
| 343 | 2020-12-26 | 2020–21 | #23 Louisville | Kentucky | SEC | Home | W | 62–59 | Regular | KFC Yum! Center |
| 344 | 2021-01-02 | 2020–21 | #23 Louisville | Boston College | ACC | Away | W | 76–64 | Regular | Conte Forum |
| 345 | 2021-01-06 | 2020–21 | #23 Louisville | #19 Virginia Tech | ACC | Home | W | 73–71 | Regular | KFC Yum! Center |
| 346 | 2021-01-13 | 2020–21 | #16 Louisville | Wake Forest | ACC | Away | W | 77–65 | Regular | Lawrence Joel Veterans Memorial Coliseum |
| 347 | 2021-01-16 | 2020–21 | #16 Louisville | Miami (FL) | ACC | Away | L | 72–78 | Regular | Watsco Center |
| 348 | 2021-01-18 | 2020–21 | #16 Louisville | Florida State | ACC | Home | L | 65–78 | Regular | KFC Yum! Center |
| 349 | 2021-01-23 | 2020–21 | #16 Louisville | Duke | ACC | Home | W | 70–65 | Regular | KFC Yum! Center |
| 350 | 2021-01-27 | 2020–21 | #25 Louisville | Clemson | ACC | Away | L | 50–54 | Regular | Littlejohn Coliseum |
| 351 | 2021-02-01 | 2020–21 | #25 Louisville | Georgia Tech | ACC | Home | W | 74–58 | Regular | KFC Yum! Center |
| 352 | 2021-02-20 | 2020–21 | #25 Louisville | North Carolina | ACC | Away | L | 54–99 | Regular | Dean Smith Center |
| 353 | 2021-02-23 | 2020–21 | #25 Louisville | Notre Dame | ACC | Home | W | 69–57 | Regular | KFC Yum! Center |
| 354 | 2021-02-27 | 2020–21 | #25 Louisville | Duke | ACC | Away | W | 80–73 OT | Regular | Cameron Indoor Stadium |
| 355 | 2021-03-06 | 2020–21 | #25 Louisville | #21 Virginia | ACC | Home | L | 58–68 | Regular | KFC Yum! Center |
| 356 | 2021-12-01 | 2021–22 | Louisville | #22 Michigan State | B10 | Away | L | 64–73 | Regular | Breslin Events Center |
| 357 | 2021-12-04 | 2021–22 | Louisville | NC State | ACC | Away | W | 73–68 | Regular | Lenovo Center |
| 358 | 2021-12-10 | 2021–22 | Louisville | DePaul | Big East | Home | L | 55–62 | Regular | KFC Yum! Center |
| 359 | 2021-12-14 | 2021–22 | Louisville | Southeastern Louisiana | Southland | Home | W | 86–60 | Regular | KFC Yum! Center |
| 360 | 2021-12-18 | 2021–22 | Louisville | Western Kentucky | CUSA | Away | L | 72–82 | Regular | E. A. Diddle Arena |
| 361 | 2021-12-29 | 2021–22 | Louisville | Wake Forest | ACC | Home | W | 73–69 | Regular | KFC Yum! Center |
| 362 | 2022-01-02 | 2021–22 | Louisville | Georgia Tech | ACC | Away | W | 67–64 | Regular | McCamish Pavilion |
| 363 | 2022-01-05 | 2021–22 | Louisville | Pittsburgh | ACC | Home | W | 75–72 | Regular | KFC Yum! Center |
| 364 | 2022-01-08 | 2021–22 | Louisville | Florida State | ACC | Away | L | 70–79 | Regular | Donald L. Tucker Civic Center |
| 365 | 2022-01-12 | 2021–22 | Louisville | NC State | ACC | Home | L | 63–79 | Regular | KFC Yum! Center |
| 366 | 2022-01-15 | 2021–22 | Louisville | Pittsburgh | ACC | Away | L | 53–65 | Regular | Petersen Events Center |
| 367 | 2022-01-19 | 2021–22 | Louisville | Boston College | ACC | Home | W | 67–54 | Regular | KFC Yum! Center |
| 368 | 2022-01-22 | 2021–22 | Louisville | Notre Dame | ACC | Home | L | 70–82 | Regular | KFC Yum! Center |
| 369 | 2022-01-24 | 2021–22 | Louisville | Virginia | ACC | Away | L | 52–64 | Regular | John Paul Jones Arena |